Sökning: "IDO1"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet IDO1.

  1. 1. Vascular targeting for enhanced cancer immunotherapy

    Författare :Maria Georganaki; Anna Dimberg; Sara Mangsbo; Lena Claesson-Welsh; Wolf Hervé Fridman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; tumor vasculature; endothelial activation; IDO1; ELTD1; tertiary lymphoid organ; Biologi; Biology;

    Sammanfattning : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. LÄS MER

  3. 2. IDO gene expression induction by DNA methylation inhibitors

    Författare :Hua Liu; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The aim was to study the effect of DNA methylation of CpG motifs in cancer cells and immune cells by use of the DNA methyltransferas (DNMT) inhibitor zebularine. In cancer cells it is known that genes can be silenced by chromosomal deletion(s). It is also known that genes can be silenced by DNA methylation or expression of micro-RNA. LÄS MER

  4. 3. Immune tolerance by interferon-alpha in experimental arthritis

    Författare :Jaya Prakash Chalise; Mattias Magnusson; Thomas Skogh; Richard O Williams; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Type I Interferons (mainly IFN-α & IFN-β) belong to a family of cytokines that possess strong antiviral and immunomodulatory properties. Pro- and/or anti-inflammatory effects of type I IFN have been observed in infectious diseases and several autoimmune diseases including SLE, MS, RA and experimental models thereof, but what defines either outcome is largely obscure. LÄS MER

  5. 4. The interplay between lipoproteins, immunity and tryptophan metabolism in atherosclerosis

    Författare :Konstantinos A Polyzos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide. Atherosclerosis is initiated by the infiltration and accumulation of low-density lipoprotein (LDL) cholesterol in the vascular wall, which activates the innate and adaptive arm of immunity, thereby causing chronic vascular inflammation. LÄS MER

  7. 5. Immunometabolic network interactions of the kynurenine pathway in cutaneous malignant melanoma

    Författare :Soudabeh Rad Pour; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is the second leading cause of mortality worldwide, and melanoma represents the most aggressive and deadliest form of skin cancer. Despite the various therapeutic approaches, metastatic melanoma is a disease with a poor prognosis. LÄS MER