Sökning: "tumor vasculature"
Visar resultat 1 - 5 av 62 avhandlingar innehållade orden tumor vasculature.
1. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor
Sammanfattning : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. LÄS MER
2. Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis
Sammanfattning : Induction of an endogenous antibody response by therapeutic vaccination could provide an alternative to cost-intensive monoclonal antibody-based treatments for cancer. Since the target of a cancer vaccine will most likely be a self-antigen, self-tolerance of the immune system must be circumvented. LÄS MER
3. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy
Sammanfattning : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. LÄS MER
4. Imaging the tumor microenvironment : the dynamics and modification of hypoxia
Sammanfattning : The tumor vasculature is poor and heterogeneous which may result in inadequate oxygenation and changed energy status. In addition the balance between cell proliferation and the rate of cell death is disturbed, which results in tumor growth. LÄS MER
5. Platelets – Multifaceted players in tumor progression and vascular function
Sammanfattning : Platelets play a crucial role for blood hemostasis, the process that prevents bleeding. In addition, platelets have been demonstrated to promote cancer progression and cancer related complications like metastasis and thrombosis. LÄS MER