Sökning: "cancer immunotherapy"

Visar resultat 1 - 5 av 120 avhandlingar innehållade orden cancer immunotherapy.

  1. 1. Cancer Immunotherapy : A Preclinical Study of Urinary Bladder Cancer

    Författare :Christina Ninalga; Thomas Tötterman; Magnus Essand; Timothy Ratliff; Uppsala universitet; []
    Nyckelord :Medicine; immunotherapy; bladder carcinoma; cancer; CpG ODNs; Adenoviral vector; CD40L; TRANCE; Lymphotactin; IL2; IL15; Medicin;

    Sammanfattning : Bacillus Calmette Guérin (BCG), or attenuated Mycobacterium bovis, is the gold standard of immunotherapy in the clinic to treat superficial bladder cancer. However, setbacks remain due to a high recurrence rate, side effects, and BCG-refractory disease. LÄS MER

  2. 2. Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

    Författare :Mohanraj Ramachandran; Magnus Essand; Di Yu; Justyna Leja-Jarblad; Richard Vile; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncolytic virus; Adenovirus; Semliki Forest virus; Cancer immunology; Chimeric antigen receptor T-cells; Immunologi; Immunology; Oncology; Onkologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : In the last decade cancer immunotherapy has taken huge strides forward from bench to bedside and being approved as drugs. Cancer immunotherapy harnesses the power of patient’s own immune system to fight cancer. LÄS MER

  3. 3. Vascular targeting for enhanced cancer immunotherapy

    Författare :Maria Georganaki; Anna Dimberg; Sara Mangsbo; Lena Claesson-Welsh; Wolf Hervé Fridman; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; tumor vasculature; endothelial activation; IDO1; ELTD1; tertiary lymphoid organ; Biologi; Biology;

    Sammanfattning : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. LÄS MER

  4. 4. Preclinical evaluation of immunostimulatory gene therapy for pancreatic cancer

    Författare :Emma Eriksson; Angelica Loskog; Tanja de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; immunotherapy; oncolytic viruses; adenoviruses; CD40L; 4-1BBL; IL-6; tumor microenvironment; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Pancreatic cancer is characterized by its desmoplastic tumor microenvironment and the infiltration of immunosuppressive cells. It is a devastating disease where most patients are diagnosed at a late stage and the treatment options are few. The development of new treatments is surly needed. LÄS MER

  5. 5. Improved cancer survival with use of common antihistamines. Epidemiological studies on the use of H1-antihistamines and survival in cancer

    Författare :Ildikó Fritz; LUCC - Lunds universitets cancercentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidemiology; histamine H1 antagonists; histamine antagonists; chemotherapy; immunotherapy;

    Sammanfattning : Cancer often results from chronic inflammation, and anti-inflammatory medications are therefore potential candidates for drug repurposing for cancer therapy. H2-antihistamines such as cimetidine have long been studied for their promise as cancer medications, but H1-antihistamines have thus far not been studied widely for this purpose. LÄS MER