Sökning: "Polycyclic aromatic compounds"

Visar resultat 16 - 20 av 49 avhandlingar innehållade orden Polycyclic aromatic compounds.

  1. 16. From source to the environment : Strategies for identification and determination of hydroxylated polycyclic aromatic hydrocarbons in complex particulate matrices

    Författare :Rozanna Avagyan; Roger Westerholm; Conny Östman; Marja-Liisa Riekkola; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; OH-PAHs; hydroxy-PAHs; particulate matter; PM; airborne particles; combustion particles; wood combustion; suspect screening; non-target screening; high resolution mass spectrometry; HRMS; atmospheric pressure photoionization; APPI; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Adverse health effects have been linked to exposure to particulate matter, and wood combustion is considered as an important source of harmful particulate matter in the urban air and environment. Hydroxylated polycyclic aromatic hydrocarbons are a group of compounds with toxic, endocrine disrupting and carcinogenic properties. LÄS MER

  2. 17. Characterization of PAC-contaminated soil with the focus on availability, leachability and biological activities

    Författare :Monika M. Lam; Magnus Engwall; Maria Larsson; Patrik Andersson; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polycyclic aromatic compounds; Availability; Mobility; Soil; Risk assessment; AhR-mediated activity; ER-mediated activity;

    Sammanfattning : Current risk assessments of polycyclic aromatic compounds (PACs)-contaminated soil are often based on the 16 priority PAHs and do not consider availability of PACs in soil sufficiently. This may lead to uncertainties of the assessment, since important contaminants can be overlooked and only a small fraction of contaminants is available for the uptake for organisms. LÄS MER

  3. 18. Factors Influencing the Yield of Mutations Induced by Polycyclic Aromatic Hydrocarbons in Mammalian Cells

    Författare :Anne Lagerqvist; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Hanspeter Naegeli; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologisk genetik; Toxicological Genetics;

    Sammanfattning : Environmental contaminants are ubiquitously present in the urban environment, this has the implication that humans are exposed to toxic and carcinogenic chemicals. Polycyclic aromatic hydrocarbons (PAH) are one type of environmental contaminants, which are produced by combustion of organic compounds. LÄS MER

  4. 19. Characterization of PAH-contaminated soils focusing on availability, chemical composition and biological effects

    Författare :Magnus Bergknut; Mats Tysklind; Dag Broman; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; polycyclic aromatic hydrocarbons; PAHs; availability; bioavailability; chemical analysis; characterization; GC-TOFMS; bioassay; toxicity; biological testing; multivariate methods; PCA; PLS; Environmental chemistry; Miljökemi;

    Sammanfattning : The risks associated with a soil contaminated by polycyclic aromatic hydrocarbons (PAHs) are generally assessed by measuring individual PAHs in the soil and correlating the obtained amounts to known adverse biological effects of the PAHs. The validity of such a risk estimation is dependent on the presence of additional compounds, the availability of the compounds (including the PAHs), and the methods used to correlate the measured chemical data and biological effects. LÄS MER

  5. 20. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity

    Författare :Anna Östergren; Eva Brittebo; Nils Gunnar Lindquist; Anne-Lie Svensson; Hans Tjälve; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; β-carboline; neuromelanin; norharman; harman; parkinsonism; Parkinson s disease; motoric impairment; behaviour; glia cells; substantia nigra; dopamine melanin; PC12 cells; ER stress; grp78; hsp90; cytochrome P450; CYP1A1; CYP1B1; blood-brain interfaces; 7; 12-dimethylbenz[a]anthracene; polycyclic aromatic hydrocarbon; endothelial cell; smooth muscle cell; bioactivation; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

    Sammanfattning : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. LÄS MER