Sökning: "Sleeping Sickness"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Sleeping Sickness.

1. 1. Oral eflornithine treatment of late-stage human African trypanosomiasis

   Författare :Mikael Boberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sleeping Sickness; Neglected Tropical Diseases; Enantiomers; Nonlinear Mixed Effects Modeling; Pharmacokinetics; Pharmacodynamics;

   Sammanfattning : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. LÄS MER

3. 2. Targets and strategies for drug development against human African sleeping sickness

   Författare :Farahnaz Ranjbarian; Anders Hofer; Staffan G. Svärd; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T. brucei thymidine kinase; T. brucei methylthioadenosine phosphorylase; FANA-A purine nucleoside analogues; essential oils;

   Sammanfattning : Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. LÄS MER

4. 3. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

   Författare :Artur Fijolek; Lars Thelander; Arne Holmgren; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; Biochemistry; Biokemi;

   Sammanfattning : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. LÄS MER

5. 4. Chronic pain and quality of life among older people

   Författare :Ulf Jakobsson; Institutionen för hälsovetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Activities of daily living; Social medicine; Socialmedicin; PMI; MPI-S; Sickness Impact Profile; LGC; SF-12; quality of life; pain relief; pain measurement; chronic pain; pain; Aged; aged 80 years and over; fatigue; samhällsmedicin; ADL;

   Sammanfattning : The overall aim was to investigate chronic pain, quality of life and factors associated with pain as well as with quality of life among older people, aged 75 years and above. Further, the aim was to investigate the use of methods for pain management and their effects for those with pain and in need of help for daily living. LÄS MER

7. 5. Work and health : epidemiological studies of sickness absence and mortality with special reference to work environment, factors outside work and unemployment

   Författare :Margaretha Voss; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The level and costs of sickness absence in Sweden have fluctuated over time and there are also important regional variations within the country with a higher rate of sickness absence in the northern part. Sickness absence tend to be more common in women than in men and several factors, besides ill health, at a societal, organisational, social and individual level have been discussed as possible causes of sickness absence. LÄS MER