Sökning: "cytochrome P450"

Visar resultat 1 - 5 av 145 avhandlingar innehållade orden cytochrome P450.

  1. 1. Theoretical Studies of Cytochrome P450

    Detta är en avhandling från Department of Theoretical Chemistry, Lund University

    Författare :Patrik Rydberg; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; quantum chemistry; Proteins; enzymology; Proteiner; enzymologi; Theoretical chemistry; transition-state force field; peroxidase; theoretical chemistry; molecular dynamics; density functional theory; cytochrome P450; porphyrin; haem; heme; kvantkemi; Teoretisk kemi;

    Sammanfattning : The cytochromes P450 are a large enzyme family that is found in all living organisms and takes part in both endogenous and exogenous metabolism. They are primarily mono-oxygenases and perform a wide range of reactions. LÄS MER

  2. 2. Bacterial cytochromes P450-Studies on Cytochrome P450 102A2 and P450 102A3 of Bacillus subtilis

    Detta är en avhandling från Department of Microbiology, Lund University

    Författare :Mattias Gustafsson; [2000]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; AbrB; Spo0A; monooxygenase; heme; Bacillus subtilis; Cytochrome P450; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Cytochromes P450 constitute a super-family of heme containing mixed function mono-oxygenases that is found in all branches of life. They introduce single oxygen atoms, mostly in the form of hydroxyl groups, into lipophilic substances and thereby render them more hydrophilic and susceptible to further reactions. LÄS MER

  3. 3. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain Role of Neuromelanin and Cytochrome P450 for Toxicity

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Östergren; Eva Brittebo; Nils Gunnar Lindquist; Anne-Lie Svensson; Hans Tjälve; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; β-carboline; neuromelanin; norharman; harman; parkinsonism; Parkinson s disease; motoric impairment; behaviour; glia cells; substantia nigra; dopamine melanin; PC12 cells; ER stress; grp78; hsp90; cytochrome P450; CYP1A1; CYP1B1; blood-brain interfaces; 7; 12-dimethylbenz[a]anthracene; polycyclic aromatic hydrocarbon; endothelial cell; smooth muscle cell; bioactivation; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; toxikologi;

    Sammanfattning : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. LÄS MER

  4. 4. Interactions between cytochrome P450 and estrogenic compounds in fish

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Linda Hasselberg; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytochrome P450; CYP1A; CYP3A; glutathione; alkylphenols; ethynylestradiol; ketoconazole; vitellogenin; Atlantic cod; rainbow trout; fish;

    Sammanfattning : DISSERTATION ABSTRACT Hasselberg, Linda. Interactions between cytochrome P450 and estrogenic compounds in fish. Department of Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden Contamination by various pollutions is an environmental concern. LÄS MER

  5. 5. Theoretical Studies of Drug-Metabolizing Cytochrome P450 Enzymes

    Detta är en avhandling från Stockholm, Sweden : KTH Royal Institute of Technology

    Författare :Junhao Li; Yaoquan Tu; Ulf Ryde; [2020]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450 enzymes; molecular dynamics; quantum chemistry; structural flexibililty; ONIOM; Theoretical Chemistry and Biology; Teoretisk kemi och biologi;

    Sammanfattning : The family of cytochrome P450 enzymes (P450s) belongs to one of the most important enzyme families in the human body. P450s are involved in the synthesis of endogenous compounds and metabolism of exogenous substances. LÄS MER