Sökning: "Patrik Andersson"
Visar resultat 1 - 5 av 36 avhandlingar innehållade orden Patrik Andersson.
1. Four applications of stochastic processes : Contagious disease, credit risk, gambling and bond portfolios
Sammanfattning : This thesis consists of four papers on applications of stochastic processes. In Paper I we study an open population SIS (Susceptible - Infective - Susceptible) stochastic epidemic model from the time of introduction of the disease, through a possible outbreak and to extinction. The analysis uses coupling arguments and diffusion approximations. LÄS MER
2. Development of in silico methods to aid chemical risk assessment : focusing on kinetic interactions in mixtures
Sammanfattning : The environment and biota are constantly exposed to numerous chemicals through contaminated food, soil, water, and air. These chemicals can be taken up and distributed to reach sensitive tissues where they may cause various effects. Many of these chemicals lack data on their environmental and human health effects. LÄS MER
3. Development of new NMR techniques and structural characterization of complexes between the N-terminal domain of the E. coli arginine repressor and operator DNA
Sammanfattning : This thesis includes the development of new solution NMR methods for the study of biomolecules and the characterization of complexes between the N-terminal domain of the E. coli arginine repressor (ArgR-N) and operator DNA. LÄS MER
4. Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model
Sammanfattning : The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and PCBs, including the highly toxic compound 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD). The toxic effects include immune suppression, endocrine disruption, impaired reproduction and carcinogenesis. LÄS MER
5. Mechanisms of tumor microenvironment in promoting metastasis
Sammanfattning : Tumor tissues contain diverse cell populations that relentlessly cross-communicate with each other in the tumor microenvironment. In addition to malignant cells, infiltration of other host cells including inflammatory cells, fibroblasts, and cells in the vessel walls in tumors significantly contribute to tumor growth and metastasis. LÄS MER