Sökning: "AhR-mediated activity"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden AhR-mediated activity.
1. Characterization of PAC-contaminated soil with the focus on availability, leachability and biological activities
Sammanfattning : Current risk assessments of polycyclic aromatic compounds (PACs)-contaminated soil are often based on the 16 priority PAHs and do not consider availability of PACs in soil sufficiently. This may lead to uncertainties of the assessment, since important contaminants can be overlooked and only a small fraction of contaminants is available for the uptake for organisms. LÄS MER
2. Chemical and bioanalytical characterisation of PAH-contaminated soils : identification, availability and mixture toxicity of AhR agonists
Sammanfattning : Contaminated soils are a worldwide problem. Polycyclic aromatic hydrocarbons (PAHs) are common contaminants in soil at former industrial areas, especially at old gasworks sites, gas stations and former wood impregnation facilities. LÄS MER
3. Molecular mechanisms of AhR mediated endocrine disruption of estrogen and retinoic acid signalling pathways
Sammanfattning : Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is considered to be one of the most toxic compounds known to man. LÄS MER
4. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Sammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER
5. Health risk assessment of dioxin-like compounds in complex samples
Sammanfattning : There are several scientific as well as political and economic reasons why the risk assessment of dioxins in complex samples needs to be further refined. Today, there seems to be no margin of safety between doses that cause suspected effects and exposure. Therefore, uncertainties and gaps in the knowledge have to be minimized. LÄS MER