Sökning: "ER-mediated activity"

Hittade 2 avhandlingar innehållade orden ER-mediated activity.

  1. 1. Characterization of PAC-contaminated soil with the focus on availability, leachability and biological activities

    Författare :Monika M. Lam; Magnus Engwall; Maria Larsson; Patrik Andersson; Örebro universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Polycyclic aromatic compounds; Availability; Mobility; Soil; Risk assessment; AhR-mediated activity; ER-mediated activity;

    Sammanfattning : Current risk assessments of polycyclic aromatic compounds (PACs)-contaminated soil are often based on the 16 priority PAHs and do not consider availability of PACs in soil sufficiently. This may lead to uncertainties of the assessment, since important contaminants can be overlooked and only a small fraction of contaminants is available for the uptake for organisms. LÄS MER

  2. 2. Molecular mechanisms of alternative estrogen receptor signaling

    Författare :Linda Björnström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Estrogen is a key regulator of growth, differentiation and function in a broad range of target tissues, including the male and female reproductive tracts, mammary gland, bone, brain and the cardiovascular system. The biological effects of estrogen are mediated through estrogen receptor a (ERalpha) and estrogen receptor beta (ERbeta), which belong to a large superfamily of nuclear receptors that act as ligand-activated transcription factors. LÄS MER