Sökning: "regulatory T-cells"

Visar resultat 1 - 5 av 309 avhandlingar innehållade orden regulatory T-cells.

1. 1. The immortalization process of T cells : with focus on the regulation of telomere length and telomerase activity

   Författare :Sofie Degerman; Göran Roos; John Sedivy; Umeå universitet; []
   Nyckelord :immortalization; senescence; T cells; Nijmegen breakage syndrome; telomere; telomerase; hTERT; generic aberrations; methylation; MEDICINE; MEDICIN; Pathology; patologi;

   Sammanfattning : Cellular immortalization is a major hallmark of cancer and is a multi-step process that requires numerous cell-type specific changes, including inactivation of control mechanisms and stabilization of telomere length. The telomeres at the chromosome ends are essential for genomic stability, and limit the growth potential of most cells. LÄS MER

3. 2. T-cell responses to Helicobacter pylori in humans and a possible role of regulatory T cells

   Författare :Anna Lundgren; Göteborgs universitet; []
   Nyckelord :Helicobacter pylori; mucosal immunology; stomach; duodenum; asymptomatic; duodenal ulcer; gastric adenocarcinoma; T cells; regulatory T cells; dendritic cells; T-cell recruitment;

   Sammanfattning : Helicobacter pylori colonize the stomach and areas of gastric metaplasia in the duodenum. The bacteria induce both local and systemic immune responses, but despite this, the infection normally persists for life and causes chronic gastritis in all infected subjects and peptic ulcers or gastric cancer in 10-20% of infected individuals. LÄS MER

4. 3. Gut bacteria, regulatory T cells and allergic sensitization in early childhood

   Författare :Hardis Rabe; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastrointestinal system; Allergy and immunology in infancy childhood: periodicals; T-Lymphocytes; Regulatory; Regulatory T cells; T cell development; bacterial colonization of the gut; allergy; allergic sensitization; cohort study; children;

   Sammanfattning : .... LÄS MER

5. 4. Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function

   Författare :Filip Ahlmanner; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colon cancer; regulatory T cells; CD39; adenosine; immune checkpoint molecules; immunosuppression; MAIT cells; cytokines; cancer-specific survival;

   Sammanfattning : In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the balance between these two counteracting forces partly determines patient outcome. LÄS MER

7. 5. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy

   Författare :Victoria Hillerdal; Magnus Essand; Johanna Olweus; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; genetically engineered T cells; chimeric antigen receptor; T cell receptor; antigen-specific T cells; immunotherapy; Immunologi; Immunology; Klinisk immunologi; Clinical Immunology;

   Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER