Sökning: "immunosuppression"

Visar resultat 1 - 5 av 170 avhandlingar innehållade ordet immunosuppression.

  1. 1. NO, Immunosuppression and Tumor Immmunotherapy

    Författare :Pontus Hegardt; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; IL-18; IFN-gamma; rat; colon carcinoma; glioma; tumor immunotherapy; immunosuppression; NO; iNOS;

    Sammanfattning : This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN-g and IL-18, induce strong anti-tumor immune response, in immunized tumor-free rats, whereas only a limited therapeutic effect is achieved in rats in which a tumor has already become established. LÄS MER

  2. 2. Mechanisms of leukemia-induced immunosuppression

    Författare :Johan Aurelius; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Immunosuppression; Immunotherapy; Reactive oxygen species; PARP-1; NK cells; T cells;

    Sammanfattning : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. LÄS MER

  3. 3. Inflammation in Parkinson’s Disease and Experimental Neural Transplantation. Role of Cellular Responses, Cytokines and Immunosuppression in Graft Rejection

    Författare :Bilal Mirza; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; graft rejection.; pig; human; rat; xenogeneic; allogeneic; syngeneic; transplantation immunology; immunosuppression; cytokines; neural transplantation; Parkinson’s Disease; inflammation; neurodegeneration; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Abstract: Parkinson’s disease (PD) is a common neurodegenerative disorder. There is no proven protection, but many treatments can partially improve symptoms. The disease is caused by monogenetic mechanisms in very few cases, but for the majority of patients the etiology is unknown. LÄS MER

  4. 4. The balance between under- and over-immunosuppression after heart transplantation with emphasis on acute cellular rejection and chronic kidney disease. Experiences from Skåne University Hospital in Lund 1988-2010

    Författare :Carl Söderlund; Kardiologi; []
    Nyckelord :heart transplantation; immunosuppression; acute cellular rejection; chronic kidney disease; generic; heart transplantation; immunosuppression; acute cellular rejection; chronic kidney disase; generic;

    Sammanfattning : Background and aims:Heart transplantation (HT) constitutes the ultimate treatment choice for end-stage heart failure. Following HT, patients require life-long immunosuppressive treatment to prevent allograft rejection. LÄS MER

  5. 5. Dynamics of Human Leukocyte Antigen-D Related expression in bacteremic sepsis

    Författare :Sara Cajander; Jan Källman; Kristoffer Strålin; Bo Söderquist; Per Åkesson; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; monocyte HLA-DR; sepsis; immunosuppression; bloodstream infection; HLA-DRA; CIITA; qRT-PCR;

    Sammanfattning : Monocytic human leukocyte antigen-D related (mHLA-DR) expression determined by flow cytometry has been suggested as a biomarker of sepsisinduced immunosuppression.In order to facilitate use of HLA-DR in clinical practice, a quantitative real-time PCR technique measuring HLA-DR at the transcription level was developed and evalutated. LÄS MER