Sökning: "caspases"

Visar resultat 6 - 10 av 75 avhandlingar innehållade ordet caspases.

  1. 6. Apoptosis induced by a human milk protein complex. Cellular and structural studies in tumour cells and bacteria

    Författare :Anders Håkansson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; nuclear uptake; caspases; mitochondria; S. pneumoniae; alpha-lactalbumin; milk; breast-feeding; Apoptosis; tumour cells; transplantation; Immunologi; serologi;

    Sammanfattning : Human milk contains a vast array of bioactive molecules, with nutritional and protective functions. This thesis describes the effects of a human milk protein complex, MAL, on tumour cells and bacteria. During our studies on the anti-adhesive properties of human milk we observed that a milk fraction killed tumour cells. LÄS MER

  3. 7. Lysosomal Membrane Permeabilization : A Cellular Suicide Strategy

    Författare :Ann-Charlotte Johansson; Karin Öllinger; Karin Roberg; Boris Zhivotovsky; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; lysosomes; lysosomal membrane permeabilization; cathepsins; Bax; Bid; mitochondria; caspases; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis signaling and execution has been achieved.The aim of this thesis was to clarify the role of lysosomal membrane permeabilization and lysosomal proteases, cathepsins, in signaling for apoptosis. LÄS MER

  4. 8. Bacterial toxins for cancer treatment

    Författare :David Johansson; Parviz Behnam-Motlagh; Kjell Grankvist; Anders Johansson; Roger Henriksson; Bo Baldetorp; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha‐toxin; AC‐toxin; mesothelioma; lung cancer; glioma; breast cancer; caspases; MAP-Kinase; verotoxin‐1; cisplatin; apoptosis; Gb3; drug resistance; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. LÄS MER

  5. 9. Mechanisms involved in amyloid induced cytotoxicity

    Författare :Johan Östman; Lars Lannfelt; Umeå universitet; []
    Nyckelord :amyloid; transthyretin; cytotoxicity; apoptosis; caspases; aggregation; molekylärbiologi; Molecular Biology;

    Sammanfattning : Amyloidoses comprise a group of diseases where normal or mutated protein precipitates into amyloid fibrils. The deposition of fibrils causes dysfunction of organs and toxicity to nervous tissue. Up to date, 24 different proteins and peptides are known to be able to form amyloid fibrils. LÄS MER

  7. 10. Hypoxic-ischemic injury in the immature brain. Role of mitochondria, caspases and NMDA receptors

    Författare :Malgorzata Puka-Sundvall; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neonatal; immature rats; hypoxia-ischemia; brain damage; calcium; mitochondria; permeability transition; apoptosis; caspase-3; NMDA receptor; electron microscopy;

    Sammanfattning : .... LÄS MER