Sökning: "caspases"

Visar resultat 16 - 20 av 72 avhandlingar innehållade ordet caspases.

  1. 16. DNA damage-induced cell death : The role of caspase-2

    Detta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Författare :Helin Vakifahmetoglu; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; caspase-2; DNA damage; mitotic catastrophe; p53;

    Sammanfattning : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. LÄS MER

  2. 17. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification

    Detta är en avhandling från Department of Theoretical Physics, Lund University

    Författare :Liwen You; Högskolan i Halmstad.; Lunds universitet.; Lund University.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik; Binding affinity; Caspase; Cleavage predition; Cleavage specifictiy; Epitope; False positive; Gaussian process; HCV; Hierarchial method; HIV; Immunology; MHC; OSRE; Protease-peptide interaction; Rule extraction; Sequence analysis; SVM; medical informatics; biomathematics biometrics; sequence analysis; rule extraction; protease-peptide interaction; immunology; hierarchical method; false positive; epitope; cleavage specificity; cleavage prediction; binding affinity; caspase; medicinsk informatik; biomatematik; Computer science; numerical analysis; systems; control; Datalogi; numerisk analys; system; kontroll;

    Sammanfattning : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. LÄS MER

  3. 18. The role of the mitochondrion in organotin-induced T-cell apoptosis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Författare :Hélène Stridh; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Apoptosis plays a central role in the development and the function of the immune system. The cell death program can, however, be inappropriately activated or suppressed under pathological conditions. Several toxins have been shown to interfere with intra-thymic processes, thereby contributing to autoimmune disorders. LÄS MER

  4. 19. Thiol redox state in apoptosis : physiological and toxicant modulation

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Stefan Nobel; Karolinska Institutet.; Karolinska Institutet.; [1997]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Apoptosis is a physiological type of cell death used to regulate the number of cells during development and im adult organs. However, apoptosis can also be inappropriately activated or inhibited under pathological conditions. One of the critical mechanisms of apoptosis is the activity of cysteine proteases belonging to the caspase family. LÄS MER

  5. 20. In vitro models to study mechanisms of neural cell death induced by toxic agents

    Detta är en avhandling från Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Författare :Roshan Tofighi; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Neurotoxicity arises when exposure to toxic agents, either naturally occurring or manmade substances, alters the normal activity and/or structure of the nervous system. This can lead to disruption of vital metabolic processes and eventually to cell death. Certain unique features of the nervous system make it particularly vunerable to toxicants, e. LÄS MER