Sökning: "caspases"
Visar resultat 16 - 20 av 75 avhandlingar innehållade ordet caspases.
16. DNA damage-induced cell death : the role of caspase-2
Sammanfattning : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. LÄS MER
17. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification
Sammanfattning : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. LÄS MER
18. The role of the mitochondrion in organotin-induced T-cell apoptosis
Sammanfattning : Apoptosis plays a central role in the development and the function of the immune system. The cell death program can, however, be inappropriately activated or suppressed under pathological conditions. Several toxins have been shown to interfere with intra-thymic processes, thereby contributing to autoimmune disorders. LÄS MER
19. Thiol redox state in apoptosis : physiological and toxicant modulation
Sammanfattning : Apoptosis is a physiological type of cell death used to regulate the number of cells during development and in adult organs. However, apoptosis can also be inappropriately activated or inhibited under pathological conditions. One of the critical mechanisms of apoptosis is the activity of cysteine proteases belonging to the caspase family. LÄS MER
20. In vitro models to study mechanisms of neural cell death induced by toxic agents
Sammanfattning : Neurotoxicity arises when exposure to toxic agents, either naturally occurring or manmade substances, alters the normal activity and/or structure of the nervous system. This can lead to disruption of vital metabolic processes and eventually to cell death. Certain unique features of the nervous system make it particularly vunerable to toxicants, e. LÄS MER