Sökning: "Karin Roberg"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Karin Roberg.

  1. 1. Lysosomal Membrane Permeabilization : A Cellular Suicide Strategy

    Författare :Ann-Charlotte Johansson; Karin Öllinger; Karin Roberg; Boris Zhivotovsky; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; lysosomes; lysosomal membrane permeabilization; cathepsins; Bax; Bid; mitochondria; caspases; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis signaling and execution has been achieved.The aim of this thesis was to clarify the role of lysosomal membrane permeabilization and lysosomal proteases, cathepsins, in signaling for apoptosis. LÄS MER

  3. 2. Head and Neck Cancer : Factors Affecting Tumour Growth

    Författare :Kaarina Sundelin; Elisabeth Paulette-Hultcrantz; Karin Öllinger; Karin Roberg; Hans Gustafsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Head and neck cancer; Chemoradiotherapy; Tumour; Malignant salivary; Metallothionein; Neo-angiogenesis; Metastases; Cytokine tumour necrosis factor-alpha; hepatocyte growth factor; Oncology; Onkologi;

    Sammanfattning : Head and neck cancer is the fifth most common cancer worldwide with an estimated annual global incidence of over 500 000 cases. These malignant tumours develop in the mucosal linings of the upper respiratory tract or in the salivary glands. The most common sites are in the oral cavity and larynx. LÄS MER

  4. 3. Immunocytochemical visualization of cathepsin D during oxidative stress

    Författare :Karin Roberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Cathepsin D is the major aspartic protease in lysosomes, and it is found in almost all animal cells. In the present studies, a pre-embedding immunocytochemical method was used to visualize cathepsin D in cultured cells. The protein can be detected at both light and electron microscopic levels by neutral-pH silver enhancement of ultrasmall (0. LÄS MER

  5. 4. The role of cathepsin D in apoptosis induced by oxidative stress

    Författare :Karin Roberg; Adi Kimchi; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The lysosomal protease cathepsin D is translocated from lysosomes to the cytosol during apoptosis induced by oxidative stress. In the present studies, the redox-cycling, xenobiotic compound naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was used to create oxidative stress in rat cardiomyocytes and human foreskin fibroblasts. LÄS MER

  7. 5. Identification of Tumor Cell- and Stroma Derived Biomarkers of Treatment Response in Head and Neck Cancer

    Författare :Anna Ansell; Karin Roberg; Ann-Charlotte Johansson; Charlotta Dabrosin; Göran Landberg; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Head and neck squamous cell carcinoma (HNSCC) poses a major health problem in the world with approximately 600 000 new cases yearly. Treatment resistance is a major problem within this patient group and despite advances in treatment strategies the overall survival rate has unfortunately not increased. LÄS MER