Sökning: "caspases"

Visar resultat 21 - 25 av 75 avhandlingar innehållade ordet caspases.

  1. 21. Neurotoxicity of methylmercury : analysis of molecular mechanisms and behavioral alterations

    Författare :Elisabetta Daré; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; oxidative stress; neurons; glia; rats; dopamine; locomotion; learning and memory; environmental pollutants;

    Sammanfattning : MethyImercury (MeHg) is a global pollutant that is toxic for the nervous system, especially during development. Contaminated fish is the main route of human exposure. Recent studies have indicated that neurological alterations in humans may occur even after exposure to fairly low levels of MeHg. LÄS MER

  3. 22. Neuronal Cell Death and Restoration in the Basal Ganglia: Implications for Huntington's and Parkinson's diseases

    Författare :Oskar Hansson; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; basal ganglia; Parkinson s disease; Huntington s disease; neural transplantation; restoration; NMDA receptor; excitotoxicity; calcium; caspase; neuronal cell death; apoptosis; transgenic mouse; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. LÄS MER

  4. 23. Anti-Apoptotic Proteins in Nerve Cell Survival and Neurodegeneration

    Författare :Laura Korhonen; Marja Jäättelä; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; neuronal cell death; XIAP; RIAP-2; Hippocalcin; Bcl-2; Bcl-X; kainic acid; DRG; estrogen; Neurovetenskap; Neurology; Neurologi; Developmental Neurosciences; medicinsk utvecklings- och neurobiologi;

    Sammanfattning : Apoptosis is a genetically regulated cell death program, which shows distinct morphological characteristics. It takes place during neuronal development and in some neurodegenerative diseases. During apoptosis, the intracellular proteins are degraded by various caspases, cysteine aspartases, which are regulated by pro- and anti-apoptotic signals. LÄS MER

  5. 24. Pharmacological Studies of CHS 828 and Etoposide Induced Tumour Cell Death

    Författare :Petra Martinsson; Stig Linder; Uppsala universitet; []
    Nyckelord :Medical sciences; Cancer chemotherapy; cell death; caspase; etoposide; CHS 828; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Antitumour properties of the cyanoguanidine CHS 828 and analogues were discovered in 1997. CHS 828 is presently in clinical phase I/II trials. This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U-937 GTB, by CHS 828 and the standard antitumour drug etoposide. LÄS MER

  7. 25. Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1

    Författare :Bogdan O Popescu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by altering neuronal signal transduction pathways, by increasing AP production or by triggering a number of proapoptotic mechanisms. The present thesis explores mechanisms by which PSs regulate signal transduction and cell death with relevance to AD. LÄS MER