Sökning: "Gb3"
Hittade 5 avhandlingar innehållade ordet Gb3.
1. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance
Sammanfattning : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. LÄS MER
2. Bacterial toxins for cancer treatment
Sammanfattning : Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. LÄS MER
3. Mechanisms of Shiga toxin-mediated signaling and toxicity
Sammanfattning : AbstractShiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli (EHEC). EHEC strains cause gastrointestinal infection and release Stx that can gain access to the circulation. Patients may develop hemolytic uremic syndrome with extensive kidney damage. LÄS MER
4. Extracellular vesicles in Shiga toxin-mediated disease
Sammanfattning : Extracellular vesicles are released during infectious, inflammatory and prothrombotic conditions. These are membrane-derived vesicles shed by cells during activation, senescence and/or apoptosis. Extracellular vesicles contain and transfer components of the parent cell from which they are shed. LÄS MER
5. Studies on the genetic basis of Pk, P and P1 blood group antigen expression
Sammanfattning : The clinically important carbohydrate P/GLOB blood group systems and collection give rise to both common (P1, P2) and rare (p, P1k, P2k) blood group phenotypes. The associated antibodies are implicated in severe transfusion reactions and recurrent spontaneous abortions. LÄS MER