Sökning: "immature rats"
Visar resultat 1 - 5 av 47 avhandlingar innehållade orden immature rats.
1. The role of bacterial endotoxin in the immature brain
Sammanfattning : Aim: Epidemiological evidence suggests that infections may increase the vulnerability of the immature brain to further insults. The aim of this thesis was to investigate the role of bacterial endotoxin (lipopolysaccharide, LPS) on hypoxic-ischemic (HI) injury in the immature rat brain, and to evaluate possible underlying mechanisms of increased sensitivity. LÄS MER
2. Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury
Sammanfattning : Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, which makes it difficult to find effective treatment. LÄS MER
3. Hypoxic-ischemic injury in the immature brain. Role of mitochondria, caspases and NMDA receptors
Sammanfattning : .... LÄS MER
4. Anabolic Androgenic Steroids : Neurobiological Effects of Nandrolone, Testosterone, Trenbolone, and Stanozolol
Sammanfattning : The use of anabolic androgenic steroids (AAS) for recreational purposes is a health concern, as long-term AAS-use in supraphysiological doses is associated with severe physical and psychological adverse effects. Several behavioral and cognitive problems are reported after long-term AAS-use, and alterations in brain morphology as well as neurotransmitter systems have been reported. LÄS MER
5. Apoptosis-related mechanisms in the immature brain after hypoxia-ischemia
Sammanfattning : Aims: To characterize the activation of caspases-3 and extracellular signal-regulated kinase (ERK) in the neonatal brain after hypoxia-ischemia (HI) injury and evaluate the neuroprotective effect of X-linked inhibitor of apoptosis (XIAP) protein, erythropoietin (EPO) and the non-erythropoietic derivative asialoEPO. Methods: Seven-day-old rats or 9-day-old mice were subjected to HI. LÄS MER