Sökning: "breast cancer"

Visar resultat 1 - 5 av 861 avhandlingar innehållade orden breast cancer.

1. 1. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

   Författare :Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
   Nyckelord :breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

   Sammanfattning : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). LÄS MER

3. 2. Clinical Aspects of Hereditary Breast Cancer

   Författare :Niklas Loman; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Cytologi; onkologi; cancerology; oncology; Cytology; Age of onset; Survival analysis; Incidence; Male breast cancer; Steroid receptors; BRCA2; BRCA1; Breast cancer; hereditary;

   Sammanfattning : A positive family history of breast cancer (BC) is one of the strongest predictors of the disease. Two major BC susceptibility genes, BRCA1 and BRCA2 were identified about a decade ago. In this thesis, studies of different biological. clinical and epidemiological aspects of hereditary BC are presented. LÄS MER

4. 3. Type IV collagen in breast and colorectal cancer : a potential biomarker of metastatic disease

   Författare :Moa Lindgren; Hanna Nyström; Ingrid Ljuslinder; Malin Sund; Kristian Pietras; Umeå universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; colorectal liver metastases; breast cancer; breast cancer metastases; tumor marker; biomarker; stroma; type IV collagen;

   Sammanfattning : Background: Metastatic colorectal cancer (mCRC) and metastatic breast cancer (mBC) are two leading causes of cancer-related mortality worldwide. Early detection of metastatic disease is critical, and sensitive, easily accessed and cost-effective biomarkers that can diagnose mBC and mCRC at an early stage would have high clinical value. LÄS MER

5. 4. Prostate cancer : epidemiological studies of risk factors

   Författare :Camilla Thellenberg Karlsson; Beatrice Malmer; Henrik Grönberg; Anders Bergh; Peter Iversen; Umeå universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; epidemiology; SNP; BRCA2; male breast cancer; inflammation; BPH; P53; Oncology; Onkologi;

   Sammanfattning : In spite of the fact that prostate cancer is the most common male cancer in both Sweden and many other countries in the developed world, little is known of risk factors and predisposing conditions. The only well recognized risk factors are age, race and familial aggregation. LÄS MER

7. 5. Molecular Cytogenetics in Sporadic Breast Cancer

   Författare :Karin Rennstam; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; oncology; Cytology; Cytologi; cancer; gene expression; gene amplification; tumor development; cDNA microarray; fluorescence in situ hybridization FISH ; breast cancer; comparative genomic hybridization CGH ; cancerology; ERBB2;

   Sammanfattning : In recent time breast cancer has become the most common form of female cancer in the western world. It has been estimated that the lifetime risk of women falling ill from the disease is 10%. The number of patients diagnosed each year has been increasing steadily since the 1970s. LÄS MER