Sökning: "Neuropeptide Y"
Visar resultat 21 - 25 av 111 avhandlingar innehållade orden Neuropeptide Y.
21. Stress-related peptides in suicide attempters
Sammanfattning : A suicide attempt is the best known predictor of completed suicide. It has long been assumed that most suicide attempts are the results of stress. LÄS MER
22. Role of Neuropeptides and Neurotrophic Factors in Seizure Modulation
Sammanfattning : The presented thesis explores role of glial cell line derived neurotrophic factor family receptor a2 (GFRa2), as well as neuropeptide Y (NPY) and galanin and their receptors in modulation of seizure activity. We demonstrate that mice lacking the GFRa2 gene (GFRa2-/-) exhibit suppressed seizure generalization in traditional and rapid kindling models. LÄS MER
23. Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin
Sammanfattning : Epilepsy is a severe chronic neurological disorder, affecting about 1% of the population. The disease is manifested by spontaneous recurrent seizures, caused by hypersynchronized neuronal activity due to imbalance in the brain between the inhibition and excitation. LÄS MER
24. Computational Modelling of Ligand Complexes with G-Protein Coupled Receptors, Ion Channels and Enzymes
Sammanfattning : Accurate predictions of binding free energies from computer simulations are an invaluable resource for understanding biochemical processes and drug action. The primary aim of the work described in the thesis was to predict and understand ligand binding to several proteins of major pharmaceutical importance using computational methods. LÄS MER
25. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors
Sammanfattning : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. LÄS MER
