Sökning: "LTD4"

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet LTD4.

  1. 1. LTD4 signalling via beta-catenin: a possible link between inflammation and cancer

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Maryna Mezhybovska; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; beta-catenin; colorectal cancer; CysLT1R; proliferation; inflammation;

    Sammanfattning : The pro-inflammatory mediator LTD4 is an important component in the pathogenesis of inflammatory conditions as inflammatory bowel diseases. Patients suffering from inflammatory bowel diseases face an increased risk of intestinal cancer development. LÄS MER

  2. 2. Regulation of survival and proliferation of human intestinal epithelial cells by leukotriene D4

    Detta är en avhandling från Sailaja Paruchuri, Entrance-78, 3rd floor, U-MAS, SE-20502, Malmo, Sweden

    Författare :Sailaja Paruchuri; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rac; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; PI3K; CREB; p90RSK; Erk-1 2; PKC; inflammation; migration apoptosis; proliferation; LTD4; cell survival;

    Sammanfattning : The pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. LÄS MER

  3. 3. Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4

    Detta är en avhandling från Anita Sjölander, Depatment of Laboratory Medicine, Division of Experimental Pathology, Malmö University Hospital, Malmö, Sweden

    Författare :Ramin Massoumi; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; PKC; vinculin; actin filament; focal adhesion; LTD4; integrin; cancerology; Cytologi; onkologi; cancer; Biochemistry; Metabolism; Biokemi; metabolism;

    Sammanfattning : Leukotrienes belong to a family of biologically active conjugated trienes that are formed from arachidonic acid via the 5-lipoxygenase pathway and are important mediators of inflammatory reactions. The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. LÄS MER

  4. 4. Influence of leukotriene D4 and cyclooxygenase-2 on cell survival

    Detta är en avhandling från Katarina Wikström, Experimental Pathology, Lund University, U-MAS, Entrance 78, 205 02 Malmö

    Författare :Katarina Wikström; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; Patologi allmän ; General pathology; colorectal cancer; inflammation; apoptosis; LTD4; COX-2; patologisk anatomi;

    Sammanfattning : The pro-inflammatory effect of leukotrienes is an important element in the pathogenesis of multiple disorders, including asthma and inflammatory bowel diseases (IBD). A serious concern for IBD patients is the increased risk of developing colorectal cancer and since there seems to be a general connection between inflammation and cancer we hypothesised that LTD4 induced signalling events could be involved in increasing the tumourgenic potential of cells. LÄS MER

  5. 5. Role of ß-catenin and Leukotriene in Colon Cancer Progression

    Detta är en avhandling från Cell Pathology

    Författare :Tavga Salim; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; β-catenin; E-cadherin; GSK-3β; inflammation; colorectal cancer;

    Sammanfattning : Abstract Colorectal cancer is the third most common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of colon cancer is inflammatory bowel disease. LÄS MER