Sökning: "Bioinformatik"

Visar resultat 1 - 5 av 314 avhandlingar innehållade ordet Bioinformatik.

  1. 1. Rule-based Models of Transcriptional Regulation and Complex Diseases Applications and Development

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Susanne Bornelöv; Jan Komorowski; Claes Wadelius; Joanna Polanska; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone modification; Transcription factor; Transcriptional regulation; Next-generation sequencing; Feature selection; Machine learning; Rule-based classification; Asthma; Allergy; Bioinformatik; Bioinformatics;

    Sammanfattning : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. LÄS MER

  2. 2. Predicting Function of Genes and Proteins from Sequence, Structure and Expression Data

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Torgeir R. Hvidsten; Uppsala universitet.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik;

    Sammanfattning : Functional genomics refers to the task of determining gene and protein function for whole genomes, and requires computational analysis of large amounts of biological data including DNA and protein sequences, protein structures and gene expressions. Machine learning methods provide a powerful tool to this end by first inducing general models from such data and already characterized genes or proteins and then by providing hypotheses on the functions of the remaining, uncharacterized cases. LÄS MER

  3. 3. Prediction, modeling, and refinement of protein structure

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Per Larsson; Arne Elofsson; Erik Lindahl; Barry Honig; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein structure prediction; Multiple alignments; Quality assessment; Molecular dynamics; Implicit solvent; Refinement; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; NATURAL SCIENCES Chemistry Theoretical chemistry Bioinformatics; NATURVETENSKAP Kemi Teoretisk kemi Bioinformatik; NATURAL SCIENCES Chemistry Theoretical chemistry Statistical mechanics; NATURVETENSKAP Kemi Teoretisk kemi Statistisk mekanik; Biochemistry; biokemi;

    Sammanfattning : Accurate predictions of protein structure are important for understanding many processes in cells. The interactions that govern protein folding and structure are complex, and still far from completely understood. However, progress is being made in many areas. Here, efforts to improve the overall quality of protein structure models are described. LÄS MER

  4. 4. The Nucleosome as a Signal Carrying Unit From Experimental Data to Combinatorial Models of Transcriptional Control

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Stefan Enroth; Jan Komorowski; Claes Wadelius; Rickard Sandberg; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Next generation sequencing; Nucleosome; Histone modification; Transcriptional regulation; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik; Bioinformatik; Bioinformatics;

    Sammanfattning : The human genome consists of over 3 billion nucleotides and would be around 2 meters long if uncoiled and laid out. Each human somatic cell contains all this in their nucleus which is only around 5 µm across. This extreme compaction is largely achieved by wrapping the DNA around a histone octamer, the nucleosome. LÄS MER

  5. 5. Regulation of Gene Expression in Multiple Myeloma Cells and Normal Fibroblasts Integrative Bioinformatic and Experimental Approaches

    Detta är en avhandling från uppsala : Acta Universitatis Upsaliensis

    Författare :Prasoon Agarwal; Helena Jernberg Wiklund; Håkan Axelson; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; Integrative bioinformatics; Epigenetics; CGGBP1; RNA polymerase; Oncology; Onkologi; Bioinformatik; Bioinformatics;

    Sammanfattning : The work presented in this thesis applies integrative genomic and experimental approaches to investigate mechanisms involved in regulation of gene expression in the context of disease and normal cell biology.In papers I and II, we have explored the role of epigenetic regulation of gene expression in multiple myeloma (MM). LÄS MER