Sökning: "glial cell line-derived neurotrophic factor"

Visar resultat 1 - 5 av 43 avhandlingar innehållade orden glial cell line-derived neurotrophic factor.

1. 1. Glial cell line-derived neurotrophic factor : expression patterns, neuronal transport, regulation, effects, and receptor dependence

   Författare :Andreas C Tomac; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glial cell line-derived neurotrophic factor GDNF ; neurturin NTN ; persephin PSP ; c Ret proto oncogene Ret ; GPI-linked receptors for the GDNF ligand family GFRas ; transforming growth factor-B TGFB ; Parkinson s disease PD ; dopaminergic DA neurons;

   Sammanfattning : Background: The mammalian nervous system depends upon trophic proteins for survival, growth and adult maintenance. These trophic factors have also been considered as potential therapeutic agents for treating human neurodegenerative disorders. LÄS MER

3. 2. Neurotrophic Factor Receptors in the Normal and Injured Visual System : Focus on Retinal Ganglion Cells

   Författare :Niclas Lindqvist; Finn Hallböök; Anders Kvanta; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; cell survival; gene expression; neurotrophic factor; receptor; retina; visual system; Neurovetenskap; Neurology; Neurologi; Developmental Neurosciences; Medicinsk utvecklings- och neurobiologi;

   Sammanfattning : The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. LÄS MER

4. 3. Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor

   Författare :Esbjörn Melin; Epilepsicentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; neuropeptide Y NPY ; Y2 receptor; GDNF; Encapsulated cell biodelivery; seizure; In-vivo;

   Sammanfattning : Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. LÄS MER

5. 4. Development and preclinical assessment of novel therapies for Epilepsy. Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition

   Författare :Eliska Waloschkova; Epilepsicentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; epileptogenesis; inhibition; cell therapy; GABAergic interneurons; mesenchymal stem cells; GDNF;

   Sammanfattning : Epilepsy is one of the leading neurological disorders affecting not only patients who suffer from seizures but also people around them and society in general. The striking one third of patients not responding to pharmacological treatments implies the necessity of developing alternative options for controlling seizures in these individuals. LÄS MER

7. 5. Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors

   Författare :Deniz Kirik; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adeno-associated virus; regeneration; neuroprotection; glial-cell-line-derived-neurotrophic factor; cell death; substantia nigra; dopamine; neurofysiologi; neuropsykologi; Neurologi; neurophysiology; neuropsychology; Neurology; tyrosine hydroxylase; sensorimotor behavior; transplantation; gene therapy;

   Sammanfattning : The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. LÄS MER