Sökning: "Bioinformatics"

Visar resultat 1 - 5 av 427 avhandlingar innehållade ordet Bioinformatics.

  1. 1. Tools and pipelines for interpreting the impacts of genetic variants

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Abhishek Niroula; Lunds universitet.; Lund University.; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Genetic variants; Machine Learning; cancer genomics; Variation interpretation;

    Sammanfattning : Next generation sequencing (NGS) methods have been widely used for diagnosis. As time and cost of sequencing has reduced sharply during the last decade, genome and exome-wide sequencing have increasingly been used. LÄS MER

  2. 2. eScience Approaches to Model Selection and Assessment Applications in Bioinformatics

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Martin Eklund; Uppsala universitet.; [2009]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; high-throughout biology; eScience; model selection; model assessment; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik;

    Sammanfattning : High-throughput experimental methods, such as DNA and protein microarrays, have become ubiquitous and indispensable tools in biology and biomedicine, and the number of high-throughput technologies is constantly increasing. They provide the power to measure thousands of properties of a biological system in a single experiment and have the potential to revolutionize our understanding of biology and medicine. LÄS MER

  3. 3. Fusing Domain Knowledge with Data Applications in Bioinformatics

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Claes Andersson; Uppsala universitet.; [2008]
    Nyckelord :Bioinformatics; cell cycle; cancer chemotherapy; predictive tests; performance estimation; bioinformatics; Bioinformatik;

    Sammanfattning : Massively parallel measurement techniques can be used for generating hypotheses about the molecular underpinnings of a biological systems. This thesis investigates how domain knowledge can be fused to data from different sources in order to generate more sophisticated hypotheses and improved analyses. LÄS MER

  4. 4. Analysis of RNA and DNA sequencing data Improved bioinformatics applications

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Benjamín Sigurgeirsson; KTH.; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA sequencing; exome sequencing; bioinformatics; gene expression; differential expression; variant calling; Biotechnology; Bioteknologi;

    Sammanfattning : Massively parallel sequencing has rapidly revolutionized DNA and RNA research. Sample preparations are steadfastly advancing, sequencing costs have plummeted and throughput is ever growing. This progress has resulted in exponential growth in data generation with a corresponding demand for bioinformatic solutions. LÄS MER

  5. 5. Improved Neuropeptide Identification Bioinformatics and Mass Spectrometry

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Maria Fälth Savitski; Uppsala universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; neuropepides; database; peptide identification; peptide fragmentation; mass spectrometry; tandem mass spectromerty; NATURAL SCIENCES Chemistry Theoretical chemistry Bioinformatics; NATURVETENSKAP Kemi Teoretisk kemi Bioinformatik;

    Sammanfattning : Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. LÄS MER