Sökning: "kindling"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet kindling.

  1. 1. Role of Neuropeptides and Neurotrophic Factors in Seizure Modulation

    Författare :Avtandil Nanobashvili; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; neurophysiology; brain slice; entorhinal cortex; hippocampus; galanin; glial cell line-derived neurotrophic factor; neuropeptide Y; epilepsy; kindling; Neurology; neurofysiologi; neuropsykologi; Neurologi;

    Sammanfattning : The presented thesis explores role of glial cell line derived neurotrophic factor family receptor a2 (GFRa2), as well as neuropeptide Y (NPY) and galanin and their receptors in modulation of seizure activity. We demonstrate that mice lacking the GFRa2 gene (GFRa2-/-) exhibit suppressed seizure generalization in traditional and rapid kindling models. LÄS MER

  3. 2. Mechanisms of Hyperexcitability in the Kindling Model of Epilepsy

    Författare :Eskil Elmer; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; Plasticity; Dentate gyrus; Mossy fibers; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Epilepsy is a syndrome characterized by recurring attacks of sudden, excessive and synchronous discharge in populations of cerebral neurons. Kindling is an animal model for complex partial epilepsy, and is particularly useful for studies on the development of the abnormal excitability underlying the generation and spread of epileptic seizures. LÄS MER

  4. 3. Maternal deprivation and mood stabilizing drugs : effects on rat brain NPY

    Författare :Henriette Husum Bak-Jensen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Maternal deprivation; stress; mood stabilizing drugs; NPY; mood disorders; depression; anhedonia; Hinders Sensitive Line rats; Amygdala-kindling; microdialysis; RIA; histochemistry.;

    Sammanfattning : Experiences of early adverse life events are more frequent among adult depressed patients than healthy subjects. Studies with non-human primates and rats show that maternal deprivation leads to changes in hypothalamic-pituitary adrenal (HPA)-axis activity/reactivity and increased levels of anxiety and alcohol preference. LÄS MER

  5. 4. Gene therapy in epilepsy: neuropeptides and neurotrophic factors

    Författare :Irene Kanter Schlifke; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; piriform cortex; hippocampus; neuropsykologi; encapsulated cells; viral vectors; GDNF; galanin; epilepsy; gene therapy; neurofysiologi;

    Sammanfattning : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. LÄS MER

  7. 5. Expression, regulation and functional aspects of the NPY Y1 receptors in rat

    Författare :Jutta Maria Kopp; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :G-protein coupled receptor; mapping; in situ hybridization; immunohistochernistry; pre- synaptic receptor; nerve injury; tracing; epilepsy; neuroprotective effect; electroconvulsive stimulation; ovary; fertility; pituitary gland.;

    Sammanfattning : The distribution of the NPY receptor subtypes, mainly of Y1 and Y2 receptors, has been studied extensively by others employing pharmacological ligand binding techniques. The major aim of this thesis was to study in detail the distribution of Y1-receptors (Y1Rs) in rat and mouse with antisera against the C-terminus (CT) of the rat Y1R using an immunohistochemical technique with enhanced sensitivity (tyramide signal amplification = TSA). LÄS MER