Sökning: "Neuropeptide Y"

Visar resultat 11 - 15 av 111 avhandlingar innehållade orden Neuropeptide Y.

1. 11. Endogenous modulators of hyperexcitability in epilepsy: electrophysiological and optogenetic delineation of neuropeptide Y mechanisms in interneurons

   Författare :Marco Ledri; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; interneurons; Epilepsy; Neuropeptide Y; synaptic transmission; synaptic plasticity; electrophysiology; optogenetics;

   Sammanfattning : Epilepsy is one of the most common neurological disorders worldwide, affecting 1% of the general population, and is characterized by a predisposition for the generation of epileptic seizures. Despite having several different aetiologies, a common underlying cause of epilepsy seems to be an acquired imbalance between excitatory and inhibitory circuits in the brain, which leads to hyperexcitability and appearance of seizures. LÄS MER

3. 12. A study of the structural requirements for receptor recognition of the neuropeptides substance P, neuropeptide Y and galanin

   Författare :Claudio Rivera; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : .... LÄS MER

4. 13. Neuropeptide Y Y1 receptor mechanisms in sympathetic vascular control

   Författare :Rickard E Malmström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Sympathetic vasoconstriction; neuropeptide Y1 Y; receptor antagonists; BIBP 3226; SR 120107A; ischaemia; pig.;

   Sammanfattning : It was demonstrated that the Y1 receptor was the predominant vascular neuropeptide Y (NPY) receptor in pig kidney and hind limb as exogenous and endogenous NPY evoked vasoconstrictor responses that were almost or totally abolished by the selective non-peptide Y1 receptor antagonist, BIBP 3226. Furthermore, renal vasoconstriction was evoked by NPY and a peptide Y1 agonist, but not by a Y 2 agonist, and these responses were strongly reduced by another non-peptide Y, receptor antagonist, SR 120107A. LÄS MER

5. 14. Neuropeptide Y - aspects of vasomotorresponses and receptor characterization

   Författare :Torun Nilsson-Bergdahl; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vasoconstriction; RT-PCR; receptor characterization; potentiation; NPY Y1 receptor; NPY; mitogenesis; hypertension; human arteries; forearm blood flow; cell culture; antisense oligodeoxynucleotides; BIBP3226; vasodilatation.; Physiology; Fysiologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Abstract The aims of the present thesis were to examine neuropeptide Y (NPY) responses in different human and guinea pig vascular beds and in cultured human vascular smooth muscle cells (VSMC) and to characterize, with different NPY agonists and the specific NPY Y1 receptor antagonist (BIBP3226), the NPY receptors involved. NPY-induced strong and potent contractions in human cerebral and subcutaneous arteries and in guinea pig basilar arteries. LÄS MER

7. 15. Molecular evolution of the neuropeptide Y receptor family : Insights from mammals and fish

   Författare :Amanda Wraith; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : Most genes in the genomes of vertebrates form families with multiple members that are more or less closely related. This thesis concerns investigations of the neuropeptide Y (NPY) family of peptides and the family of receptors to which these peptides bind, the NPY receptors. LÄS MER