Sökning: "signalsubstans"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet signalsubstans.

1. 1. Immunocytochemical studies of excitatory amino acid neurotransmitters and transporters in the spinal cord and nucleus submedius

   Författare :Stefan Persson; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurophysiology; neuropsychology; Neurology; VGLUT2; VGLUT1; pain; somatosensory; thalamus; immunogold; glutamate; aspartate; dorsal horn; excitatory amino acids; spinal cord; neurofysiologi; Neurologi;

   Sammanfattning : The amino acid glutamate is today regarded as the main fast excitatory neurotransmitter in the central nervous system and a large body of evidence support that glutamate serves as a neurotransmitter in primary afferent terminals in the spinal cord. Previous evidence also suggests that the closely related amino acid aspartate may serve a similar role in some primary afferent terminals. LÄS MER

3. 2. Bacterial cytochromes P450-Studies on Cytochrome P450 102A2 and P450 102A3 of Bacillus subtilis

   Författare :Mattias Gustafsson; Avdelningen för medicinsk mikrobiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; AbrB; Spo0A; monooxygenase; heme; Bacillus subtilis; Cytochrome P450; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

   Sammanfattning : Cytochromes P450 constitute a super-family of heme containing mixed function mono-oxygenases that is found in all branches of life. They introduce single oxygen atoms, mostly in the form of hydroxyl groups, into lipophilic substances and thereby render them more hydrophilic and susceptible to further reactions. LÄS MER

4. 3. Central nervous system targets for micturition control

   Författare :Rikard Pehrson; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; central nervous system; Micturition; 5-HT; GABA; tramadol; NAD-299; CGP62349; apomorphine; cerebral infarction; toxikologi; farmaci; farmakognosi; Farmakologi; toxicology; pharmacy; pharmacognosy; Pharmacological sciences;

   Sammanfattning : Normal urine storage and bladder emptying are controlled by the central (CNS) as well as the peripheral nervous system. Dysfunction of these mechanisms can lead to urinary incontinence. Urinary tract dysfunctions have symptomatically been treated mainly with drugs acting peripherally. LÄS MER

5. 4. Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors

   Författare :Knut Kotarsky; Slemhinnans immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Metabolism; Biochemistry; metabolism; leukotrieneB4; thiazolidinedione; 9-HODE; fatty acid; luciferase; GFP; reporter gene; preclinical assay; receptor; GPCR;

   Sammanfattning : Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. LÄS MER

7. 5. Effect of elevated pCO2 and environmental oxazepam on the behavior and physiology of teleost fish

   Författare :Laura E. Vossen; Svante Winberg; Robert Gerlai; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fish; GABA; CO2; ocean acidification; pharmaceutical pollution; oxazepam;

   Sammanfattning : This doctoral thesis investigated the effect of two aquatic pollutants on the behavior and physiology of teleost fish: i) elevated concentrations of carbon dioxide (CO2) in the context of ocean acidification and ii) low concentrations of the anxiolytic pharmaceutical oxazepam in the context of pharmaceutical pollution.Anthropogenic emissions of CO2 are lowering the pH of the oceans. LÄS MER