Sökning: "phospholipase D"

Visar resultat 6 - 10 av 31 avhandlingar innehållade orden phospholipase D.

  1. 6. OX1 Orexin Receptor Signalling to Phospholipases

    Författare :Marie Ekholm; Jyrki Kukkonen; Graeme Milligan; Uppsala universitet; []
    Nyckelord :orexin; phospholipase; Calcium; cell signalling; G protein coupled receptor; ERK; live-cell imaging; arachidonic acid; diacylglycerol;

    Sammanfattning : The neuropeptides orexin-A and orexin-B were discovered in 1998 and were first described as regulators of feeding behaviour. Later research has shown that they have an important role in the regulation of sleep. Two G protein-coupled receptors, OX1 and OX2 orexin receptors, mediate the cellular responses to orexins. LÄS MER

  2. 7. Calcium and Phospholipases in Orexin Receptor Signaling

    Författare :Lisa Johansson; Jyrki Kukkonen; Karl Åkerman; Christopher S. Leonard; Uppsala universitet; []
    Nyckelord :Physiology; orexin; receptor; calcium; phospholipase; cell signaling; GPCR; Fysiologi;

    Sammanfattning : The neuropeptides orexin-A and -B act as endogenous ligands for G-protein-coupled receptors (GPCRs) called OX1 and OX2 receptors. Previous observations have established that orexin receptors have an ability to couple to different G-proteins and signaling pathways and induce Ca2+ elevations via both receptor-operated Ca2+ channels (ROCs) and store-operated Ca2+ channels (SOCs). LÄS MER

  3. 8. Phosphatidylethanol in blood as a marker of alcohol abuse

    Författare :Arthur Varga; Associativ inlärning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PKC; MCV; ELSD; HPLC; red blood cell; phospholipase D; phosphatidylethanol; ethanol; alcohol abuse; state marker; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Biological markers offer a way of assessing ethanol intake and determining whether a health problem is alcohol related. This study investigated the use of phosphatidylethanol (PEth) in blood as a new marker of alcohol abuse. LÄS MER

  4. 9. Phosphatidylethanol - formation and degradation in blood and organs

    Författare :Steina Aradottir; Bröstca-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diagnostik; Public health; Diagnostics; organs; blood; HPLC; in vitro; in vivo; human; rat; phosphatidylethanol; phospholipase D; alcohol; ethanol; epidemiology; Folkhälsa; epidemiologi;

    Sammanfattning : Phosphatidylethanol (PEth) is an abnormal phospholipid formed exclusively by the action of phospholipase D (PLD) in the presence of ethanol. The degradation of PEth is slow and due to its accumulation in some cells the possibility to use PEth as marker of ethanol intake has been proposed. LÄS MER

  5. 10. Hyperthermia-responsive liposomal systems

    Författare :Yujia Jing; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; MEDICAL AND HEALTH SCIENCES; cationic lipid; asymmetry; phospholipase; liposomes; flip-flop; hyperthermia; phase transition; supported lipid membranes; drug delivery;

    Sammanfattning : Abstract Sophisticated liposomal systems are emerging at an increasing rate to meet the demands for multifunctional drug carriers in chemotherapies in combined with hyperthermia. For example, liposomal drug carriers for temperature-controlled drug release under hyperthermic conditions have recently been tested in clinical trials. LÄS MER