Sökning: "phosphatidylethanol"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet phosphatidylethanol.

  1. 1. Phosphatidylethanol - formation and degradation in blood and organs

    Författare :Steina Aradottir; Bröstca-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diagnostik; Public health; Diagnostics; organs; blood; HPLC; in vitro; in vivo; human; rat; phosphatidylethanol; phospholipase D; alcohol; ethanol; epidemiology; Folkhälsa; epidemiologi;

    Sammanfattning : Phosphatidylethanol (PEth) is an abnormal phospholipid formed exclusively by the action of phospholipase D (PLD) in the presence of ethanol. The degradation of PEth is slow and due to its accumulation in some cells the possibility to use PEth as marker of ethanol intake has been proposed. LÄS MER

  2. 2. Phosphatidylethanol in blood as a marker of alcohol abuse

    Författare :Arthur Varga; Associativ inlärning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PKC; MCV; ELSD; HPLC; red blood cell; phospholipase D; phosphatidylethanol; ethanol; alcohol abuse; state marker; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Biological markers offer a way of assessing ethanol intake and determining whether a health problem is alcohol related. This study investigated the use of phosphatidylethanol (PEth) in blood as a new marker of alcohol abuse. LÄS MER

  3. 3. Methodological and clinical evaluation of the alcohol marker phosphatidylethanol (PEth)

    Författare :Lisa Walther; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :alcohol; alcohol marker; alcohol use disorder; phosphatidylethanol; PEth; phosphatidylcholine; alcohol use; gastric bypass; LC-MS MS;

    Sammanfattning : .... LÄS MER

  4. 4. Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption

    Författare :Andrea deBejczy; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :alcohol dependence; mirtazapine; varenicline; org 25935; alcohol markers; phosphatidylethanol; randomized controlled clinical trials RCT ; treatment; glycine transporter inhibitor; nAChR;

    Sammanfattning : This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. LÄS MER

  5. 5. Development and application of an LC-MS method for the alcohol biomarker phosphatidylethanol (PEth) in blood

    Författare :Yufang Zheng; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : Objective biomarkers tracing alcohol consumption are demanded in many situations when alcohol drinking is in focus, e.g. during monitoring of patient in a treatment program, in forensic medicine, workplace testing or biochemical validation of selfreport in research. LÄS MER