Sökning: "ERK"

Visar resultat 1 - 5 av 158 avhandlingar innehållade ordet ERK.

  1. 1. Apoptosis-related mechanisms in the immature brain after hypoxia-ischemia

    Författare :Xiaoyang Wang; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia-ischemia; neonatal; caspase; ERK; XIAP; EPO; asialoEPO; brain;

    Sammanfattning : Aims: To characterize the activation of caspases-3 and extracellular signal-regulated kinase (ERK) in the neonatal brain after hypoxia-ischemia (HI) injury and evaluate the neuroprotective effect of X-linked inhibitor of apoptosis (XIAP) protein, erythropoietin (EPO) and the non-erythropoietic derivative asialoEPO. Methods: Seven-day-old rats or 9-day-old mice were subjected to HI. LÄS MER

  2. 2. Ischemic Tolerance and Cell Signaling in the Rat Brain

    Detta är en avhandling från Wallenberg Neuroscience Center, BMC, Lund University

    Författare :Mehrdad Shamloo; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; preconditioning; cell death; tyrosine phosphorylation; tolerance; ERK; Calpain; CaMKII; PKC; protection; Brain; ischemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : A brief period of sublethal ischemia in the brain induces resistance to a subsequent, otherwise lethal ischemic insult. This phenomenon is known as ischemic tolerance or preconditioning. A model of ischemic preconditioning in the rat brain using the two-vessel occlusion model of global cerebral ischemia was established. LÄS MER

  3. 3. Transforming Growth Factor-b, Regulatory functions on normal lymphocytes and tumor outgrowth Regulatory functions on normal lymphocytes and tumor outgrowth

    Detta är en avhandling från BMC Biomedical Centre, Lund University

    Författare :Åsa Schiött; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-b; monocyte; rat; costimulation; Th2; ERK; tumor; TIL; Immunology; serology; Immunologi; transplantation; T-lymphocyte; serologi;

    Sammanfattning : Transforming growth factor-beta (TGF-b) is a well-characterised growth regulatory factor, which acts on most cell types. This thesis has focused on the regulatory roles of TGF-b on normal lymphocytes. One interesting finding is that TGF-b acts both costimulatory and inhibitory on T-lymphocytes. LÄS MER

  4. 4. Intracellular components involved in parathyroid sensing of extracellular calcium

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Isaac G. Onyango; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Parathyroid hormone; secretion; Src kinase; ERK; PI 3-kinase; PKC; extracellular calcium; parathyroid cell; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : Parathyroid glands are the primary regulator of extracellular calcium ([Ca2+]e). Ca2+ plays a key role in many fundamental biological processes and is also an essential structural component of the skeleton. The parathyroid chief cells detect small changes in [Ca2+]e and respond by altering the secretion of parathyroid hormone (PTH). LÄS MER

  5. 5. Neural Stem Cell Differentiation and Migration

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Erlandsson; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; CNS; stem cells; neuron; PDGF; SCF; differentiation; migration; ERK; Medicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Neural stem cells are the precursors of neurons, astrocytes and oligodendrocytes. During neural development, the division of stem cells takes place close to the lumen of the neural tube, after which they migrate to their final positions within the central nervous system (CNS). LÄS MER