Sökning: "pancreatic alpha cells"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden pancreatic alpha cells.

  1. 1. Regulation of glucagon secretion from pancreatic alpha cells

    Författare :Yang De Marinis; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epac2; glucagon secretion; pancreatic alpha cells; K- ATP channel; N-type Ca2 channel; L-type Ca2 channel; GLP-1; cAMP; PKA; Adrenaline; PKC;

    Sammanfattning : Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. LÄS MER

  2. 2. Microencapsulation of Pancreatic Islets : A Non-Vascularised Transplantation Model

    Författare :Sara Bohman; Arne Andersson; Aileen King; Stellan Sandler; Eduard Montanya; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Microencapsulation; Islet transplantation; revascularisation; alpha-cell; exendin-4; islet amyloid; Cell biology; Cellbiologi;

    Sammanfattning : Transplantation of pancreatic islets is a potential treatment of type 1 diabetes that aims to restore normal blood glucose control. By encapsulating the islets in alginate, they can be protected from rejection. LÄS MER

  3. 3. Pancreatic Growth and Secretion. An Experimental Study on Growth Factors in Rat and Mouse

    Författare :Claes Hjalmarsson; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; PBD; insulin; B-cells; bile; pancreatic cancer; intestine; secretion; pancreas; proliferation; tyrphostins; CCK; epidermal growth factor; transforming growth factor alpha; cancerology; Cytologi; onkologi; cancer; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : The pancreas is a central organ in the digestion of food as well as in glucose metabolism. Its two major functions are exocrine and endocrine secretion. LÄS MER

  4. 4. Studies of the tumor microenvironment : Local and systemic effects exerted by the cross-talk between tumor and stroma cells in pancreatic cancer

    Författare :Vegard Tjomsland; Marie Larsson; Arne Östman; Linköpings universitet; []
    Nyckelord :Pancreatic cancer; cancer associated fibroblasts; dendritic cells; IL-1alpha; tumor microenvironment; inflammation; bukspottkörtelcancer; Bukspyttkjertel kreft; MEDICINE; MEDICIN;

    Sammanfattning : Pancreatic cancer is one of the most lethal cancers and despite all research efforts the last 50 years, there are still no effective therapy for this terrible disease. Until quite recently most research in the field of pancreatic duct adenocarcinoma (PDAC) was focused on the tumor cells and mechanisms essential for their proliferation and survival. LÄS MER

  5. 5. CFTR in pancreatic islets

    Författare :Anna Edlund; Diabetes - öcellsexocytos; []
    Nyckelord :CFTR; CF; CFRD; Cystic fibrosis; Cystisk fibros; Diabetes; Insulin; Beta cell; Glukagon; Glucagon; Alpha cell; Alfa-cell; Anoctamin; ANO1; ANO;

    Sammanfattning : AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. LÄS MER