Sökning: "cancer associated fibroblasts"

Visar resultat 1 - 5 av 63 avhandlingar innehållade orden cancer associated fibroblasts.

  1. 1. Type IV collagen in breast and colorectal cancer : a potential biomarker of metastatic disease

    Författare :Moa Lindgren; Hanna Nyström; Ingrid Ljuslinder; Malin Sund; Kristian Pietras; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; colorectal liver metastases; breast cancer; breast cancer metastases; tumor marker; biomarker; stroma; type IV collagen;

    Sammanfattning : Background: Metastatic colorectal cancer (mCRC) and metastatic breast cancer (mBC) are two leading causes of cancer-related mortality worldwide. Early detection of metastatic disease is critical, and sensitive, easily accessed and cost-effective biomarkers that can diagnose mBC and mCRC at an early stage would have high clinical value. LÄS MER

  3. 2. The identification and functional evaluation of novel cancer-associated fibroblast subtypes and matrisome proteins in pancreatic cancer

    Författare :Joshua Cumming; Daniel Öhlund; Cedric Patthey; Jenny Persson; Claus Jørgensen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer-associated fibroblast CAF ; Single-cell RNA sequencing scRNAseq ; Pancreatic ductal adenocarcinoma PDAC ; Tumor microenvironment TME ; Extracellular matrix ECM ; Organoid-based co-culture model; Drug-screen; Oncology; onkologi;

    Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an extensive desmoplastic stroma. The stroma is the site of intricate communication between malignant cells and their surrounding environment. LÄS MER

  4. 3. Growth factor signaling in the breast tumor microenvironment

    Författare :Matteo Bocci; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Tumor microenvironment; Angiogenesis; Cancer-associated fibroblasts; PDGF-C; ALK1;

    Sammanfattning : Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. LÄS MER

  5. 4. Identification and clinical evaluation of senescence-associated markers to distinguish melanocytic nevi from melanomas

    Författare :Kyriakos Orfanidis; Ingrid Synnerstad; Jakob Wikström; John Paoli; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; senescence; nevi; melanoma; melanocytes; fibroblasts; ultraviolet UV radiation;

    Sammanfattning : Melanoma is a form of cancer that develops in melanocytes. While it represents only 5% of skin malignancies, it is the most aggressive and lethal. Benign proliferation of these cells form the melanocytic nevi. The definitive diagnosis of melanocytic nevi or melanoma lesions is histopathologic. LÄS MER

  7. 5. Cellular effects of ionizing radiation : Relevant for understanding cancer risk after medical and environmental radiation exposures

    Författare :Pamela Chiaka Akuwudike; Andrzej Wojcik; Lovisa Lundholm; Kerstin Borgmann; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation; DNA damage; radiation-induced carcinogenesis; second primary cancer; cisplatin chemoradiotherapy; dose fractionation; low dose; low dose rate; dose and dose rate effectiveness factor DDREF ; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Radiation-induced cancers are stochastic and delayed effects of exposure to ionizing radiation. The dose-response relationship for radiation-induced cancers at both low dose/low dose rates and high doses (doses encountered during radiotherapy) remains unclear. LÄS MER