Sökning: "pancreatic alpha cells"

Visar resultat 11 - 15 av 35 avhandlingar innehållade orden pancreatic alpha cells.

1. 11. Studies of neuropeptides in pancreatic beta cell function with special emphasis on islet amyloid polypeptide (IAPP)

   Författare :Ella Karlsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; alpha cell; amylin; beta cell; chromogranin; growth; IAPP; insulin; islet amyloid polypeptide; leptin; NOD mice; pancreastatin; pancreatic islet; proliferation; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : The presence of protein amyloid in pancreas and its association to diabetes was first described 100 years ago in 1901, but was not identified as Islet Amyloid Polypeptide (IAPP) until 1986. The aim of the present work was to determine the role of the beta cell hormone, IAPP, in normal pancreatic islet physiology and during early disturbances of islet function. LÄS MER

3. 12. Prevention of type 1 diabetes mellitus in experimental studies

   Författare :Maria Holstad; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cytokines; inducible nitric oxide synthase; nitric oxide; NOD mice; pancreatic islets; prolactin; syngeneic islet transplantation; tumour necrosis factor alpha; type 1 diabetes mellitus; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : The aim of the study was to examine the immune response and different immunoprotective strategies in experimental type 1 diabetes mellitus. The autoimmune destruction of the insulin-producing pancreatic β-cells that leads to type 1 diabetes is complex and incompletely understood. LÄS MER

4. 13. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes

   Författare :Tasnim Dayeh; Diabetes - epigenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG-SNP; glucagon secretion; insulin secretion; human pancreatic islets; DNA methylation; Epigenetics;

   Sammanfattning : Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. LÄS MER

5. 14. Quantification of gene expression in single cells

   Författare :Martin Bengtsson; Islet cell physiology; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Biomedical sciences; Biomedicinska vetenskaper; quantitative gene expression analysis; single cell PCR; islets of Langerhans;

   Sammanfattning : Studies of apparently homogeneous cell populations and single cells often give highly divergent results. Cells exhibit varying responsiveness to stimuli and gene expression and they are in many aspects stochastic and unpredictable. We have developed a method to measure gene expression quantitatively in individual cells with real-time RT-PCR. LÄS MER

7. 15. Expression of the glucose-6-phosphatase system in endocrine cells

   Författare :Bee-Hoon Goh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Glue os e- 6 -phphspatas e; G6PC; G6PT1; G6PC2; G6PC3; pancreatic islets; InR1G9 cells; GLUTag cells; glucagon producing a-cells; GLP-1 producing L-cells.;

   Sammanfattning : Glucose-6-phosphatase (G6pase) is a multi-component enzyme system, which regulates the catalysis of gluco se-6 -phosphate (G6P) to glucose and inorganic phosphate. This reaction constitutes the final steps of both gluconeogenesis and glycogenolysis, processes that are critical in the maintenance of glucose homeostasis. LÄS MER