Sökning: "glucagon secretion"
Visar resultat 1 - 5 av 78 avhandlingar innehållade orden glucagon secretion.
1. Signal Transduction of Glucagon Secretion
Sammanfattning : Diabetes mellitus is a bihormonal disorder with hyperglycemia due to deficiency of insulin and hypersecretion of glucagon. To improve diabetes treatment it is important to clarify the signal transduction of glucagon secretion. LÄS MER
2. Origin, release and functional significance of the novel gastric hormone ghrelin
Sammanfattning : The novel gastric hormone ghrelin was discovered by virtue of its ability to release growth hormone (GH) via interaction with the so-called GH-secretagogue receptor (GHS-R). Earlier only synthetic agents were known to bind with the GHS-R, hence, ghrelin is the first identified endogenous ligand. LÄS MER
3. α-Cell signalling in glucose-regulated glucagon secretion
Sammanfattning : Glucagon is a blood glucose-elevating hormone released from α-cells in the islets of Langerhans during hypoglycaemia. Glucagon is critical for glucose homeostasis and inappropriate regulation of its secretion underlies both impaired counter-regulation of hypoglycaemia and chronic hyperglycaemia in diabetes patients. LÄS MER
4. Regulation of glucagon secretion from pancreatic alpha cells
Sammanfattning : Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. LÄS MER
5. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon
Sammanfattning : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. LÄS MER