Sökning: "K- ATP channel"
Visar resultat 1 - 5 av 25 avhandlingar innehållade orden K- ATP channel.
1. Ion Transport in Glial and Neuroblastoma Cells
Sammanfattning : The aim of this thesis has been to increase our understanding of the ion channel function and the ion transport mechanisms in glial cells. The analysis has also covered Na channel function in human neuroblastoma cells in order to get a basis for similar studies of glial cells In paper I isotopes 42K and 201 Tl were used to compare the K+ transport properties in cell lines from human malignant gliomas (U-251MG and Tp-378MG), carcinomas, and brain metastasis. LÄS MER
2. Regulation of glucagon secretion from pancreatic alpha cells
Sammanfattning : Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. LÄS MER
3. Studies on molecular mechanisms in calcium signaling and cellular energy consumption
Sammanfattning : Ion signaling plays fundamental role in cell survival. Na+ and Ca2+ are critical players in ion signaling. Cells spend the major amount of energy to maintain and regulate Na+ and Ca2+ gradients across the cell membrane. Any disruption in cellular energy consumption by plasma membrane ATPases affects ion signaling and vice versa. LÄS MER
4. Metabolic signals and the ATP-sensitive potassium channel in the pancreatic beta-cell
Sammanfattning : ATP-sensitive K+ (KATP) channels are widely distributed in a variety of tissues and cell types. KATP channels are comprised of two subunits, a pore forming subunit (Kir6.x) and a regulatory sulfonylurea receptor (SURx). Both subunits are required for fully functional channels. LÄS MER
5. A study of potassium channel activation as a pharmacological principle for vasodilation of cerebral blood vessels
Sammanfattning : Increasing [K+]o is intimately coupled to progressive ischemia and reduced CBF. In isolated cerebral and mesenteric arteries, it was found that significant differences in the vascular responses to [K+]o exist. Among the species studied, human cerebral arteries were the most sensitive artery to increasing [K+]o. LÄS MER