Sökning: "aspartic protease"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden aspartic protease.

  1. 1. Design and Synthesis of Serine and Aspartic Protease Inhibitors

    Författare :Fredrik Wångsell; Ingemar Kvarnström; Olle Karlsson; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; Organic synthesis; Organisk syntes;

    Sammanfattning : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. LÄS MER

  2. 2. Design and Synthesis of Malarial Aspartic Protease Inhibitors

    Författare :Karolina Ersmark; Anders Hallberg; Michael Rowley; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; malaria; plasmepsin; aspartic protease; protease inhibitor; macrocycle; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. LÄS MER

  3. 3. Cyclic Sulfamide HIV-1 Protease Inhibitors : Design, Synthesis and Modelling

    Författare :Anna Ax; Anders Karlén; Anders Hallberg; Tommy Liljefors; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; AIDS; HIV; protease inhibitor; aspartic protease; molecular modelling; 3D-QSAR; CoMFA; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Ten years ago, the first protease inhibitor targeting the human immunodeficiency virus (HIV) was approved for clinical use. Highly active antiretroviral therapy (HAART), which combined protease and reverse transcriptase inhibitors, quickly became the standard therapy for treating patients infected with HIV and Acquired Immune Deficiency Syndrome (AIDS). LÄS MER

  4. 4. Design and Synthesis of Aspartic and Serine Protease Inhibitors : Targeting the BACE-1 and the HCV NS3 Protease

    Författare :Fredrik Wångsell; Mats Larhed; Jari Yli-Kauhaluoma; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; BACE-1; transition state mimetic; tertiary hydroxyl group; hydroxyethylene; statine; hydroxyethylamine; hepatitis C; HCV NS3; bioisostere; protease inhibitor.; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : This thesis describes work done to design and synthesize protease inhibitors, with the intention of developing therapeutic agents for Alzheimer’s disease (AD) and the chronic liver condition caused by infection of the hepatitis C virus (HCV). AD is the most common form of dementia, and HCV infection is the primary reason for liver transplantation in industrialized countries. LÄS MER

  5. 5. Tertiary Alcohol- or β-Hydroxy γ-Lactam-Based HIV-1 Protease Inhibitors : Microwave Applications in Batch and Continuous Flow Organic Synthesis

    Författare :Per Öhrngren; Mats Larhed; Knud J. Jensen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; MEDICIN OCH HÄLSOVETENSKAP; ENGINEERING AND TECHNOLOGY; MEDICAL AND HEALTH SCIENCES; HIV; AIDS; protease inhibitor; aspartic protease; lactam; tertiary alcohol; continuous-flow; microwave; non-resonant; MAOS; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Since the outbreak of the HIV/AIDS pandemic in the 1980s, the disease has cost the lives of over 30 million people, and a further 33 million are currently living with the HIV infection. With the appropriate treatment, HIV/AIDS can today be regarded as a chronic but manageable disease. LÄS MER