Sökning: "Organisk syntes"

Visar resultat 1 - 5 av 133 avhandlingar innehållade orden Organisk syntes.

1. 1. Optimering i organisk syntes : betingelser, system, syntesvägar

   Författare :Lars Hansson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; Response surface method; PLS method; Silylation; Enolether; Unsaturated ketones; Diketones; Geosmin synthesis; Onepot procedure;

   Sammanfattning : This thesis deals with different optimization problems encountered in organic synthesis. The use of response surface, sequential simplex and PLS techniques, for simultanious optimization of yield and suppression of side reactions is investigated. This is illustrated by an example of enamine synthesis, were a side reaction was a serious problem. LÄS MER

3. 2. Diaryliodonium Salts : Development of Synthetic Methodologies and α-Arylation of Enolates

   Författare :Marcin Bielawski; Berit Olofsson; Antonio Togni; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hypervalent Iodine Compounds; One-Pot Synthesis; Regiospecific Synthesis; Aromatic Substitution; Aryl Iodides; Arenes; Boronic Acids; Heteroaromatics; Arylations; Reaction Mechanisms; Density Functional Calculations; Large Scale Synthesis; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes novel reaction protocols for the synthesis of diaryliodonium salts and also provides an insight to the mechanism of α-arylation of carbonyl compounds with diaryliodonium salts.  The first chapter gives a general introduction to the field of hypervalent iodine chemistry, mainly focusing on recent developments and applications of diaryliodonium salts. LÄS MER

4. 3. Synthesis of O-linked Carbasugar Analogues of Galactofuranosides and N-linked Neodisaccharides

   Författare :Jens Frigell; Ian Cumpstey; George Fleet; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbasugar; galactofuranose; mycobacterium; tuberculosis; ring-closing metathesis; GlfT2; galactan; epoxide-opening; pseudodisaccharide; etherification; regioselective; carbohydrate; carbocycles; glycomimetics; glucosidase; neodisaccharides; Mitsunobu; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Sammanfattning : In this thesis, carbohydrate mimicry is investigated through the syntheses of carbohydrate analogues and evaluation of their inhibitory effects on carbohydrate-processing enzymes. Galactofuranosides are interesting structures because they are common motifs in pathogenic microorganisms but not found in mammals. M. LÄS MER

5. 4. Development of organocatalytic asymmetric transformations

   Författare :Ismail Ibrahem; Armando Cordova; Stephen Hanessian; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Asymmetric Catalysis; α-amino acids; Aldehydes; Ketones; α-Aminomethylation; Aziridination; Hydrophosphination; Diarylprolinol; Proline derivatives; Organic synthesis; Organisk syntes; Organic Chemistry; organisk kemi;

   Sammanfattning : The ability of amino acids and amino acid derivatives to mediate various organocatalytic asymmetric transformations has been investigated and applied in the development of various reactions. This work describes the development of a direct catalytic asymmetric α-aminomethylation of ketones and aldehydes, a catalytic asymmetric aziridination, hydrophosphination and amination of α,β-unsaturated aldehydes. LÄS MER

7. 5. Design & Synthesis of Protein Interacting Affinity Ligands and Protease Inhibitors

   Författare :Charlotta Lindquist; Hans Adolfsson; Fredrik Almqvist; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Sammanfattning : There is a growing need of both protein drugs and synthetic drugs in the fight against many life-threatening diseases. The first part of this thesis deals with the design and synthesis of high affinity binding ligands for the purification of protein drugs. LÄS MER