Sökning: "tertiary hydroxyl group"

Hittade 3 avhandlingar innehållade orden tertiary hydroxyl group.

  1. 1. Design and Synthesis of Aspartic and Serine Protease Inhibitors : Targeting the BACE-1 and the HCV NS3 Protease

    Författare :Fredrik Wångsell; Mats Larhed; Jari Yli-Kauhaluoma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; BACE-1; transition state mimetic; tertiary hydroxyl group; hydroxyethylene; statine; hydroxyethylamine; hepatitis C; HCV NS3; bioisostere; protease inhibitor.; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : This thesis describes work done to design and synthesize protease inhibitors, with the intention of developing therapeutic agents for Alzheimer’s disease (AD) and the chronic liver condition caused by infection of the hepatitis C virus (HCV). AD is the most common form of dementia, and HCV infection is the primary reason for liver transplantation in industrialized countries. LÄS MER

  3. 2. Convergent and Tandem Strategies in Iridium-Catalyzed Asymmetric Hydrogenation of Olefins

    Författare :Luca Massaro; Pher Andersson; Antoni Riera; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Enantioconvergent catalysis; asymmetric hydrogenation; iridium catalysis; tandem reaction; mechanistic investigation; Organic Chemistry; organisk kemi;

    Sammanfattning : The work presented in this thesis describes the development of enantioselective methods and their corresponding mechanistic studies to expand the field of catalytic asymmetric hydrogenation. Efficient catalytic systems based on iridium complexes were designed and employed in convergent and tandem strategies to prepare important optically enriched organic compounds. LÄS MER

  4. 3. Palladium-Catalyzed Nucleophilic Substitution of Alcohols : Mechanistic Studies and Synthetic Applications

    Författare :Supaporn Sawadjoon; Joseph Samec; Takao Ikariya; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; nucleophilic substitution; mechanism; Organic Chemistry; Organisk kemi;

    Sammanfattning : This thesis deals with the palladium-catalyzed nucleophilic substitution of π-activated alcohols in which the C–O bond of a non-manipulated hydroxyl group is cleaved. The thesis is divided in two chapters describing two different catalytic systems. LÄS MER