Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet macrocycle.
1. Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)
Sammanfattning : Peptidomimetics derived from the bioactive hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) have been designed and synthesized. These peptidomimetics are aimed at inhibiting the insulin-regulated amino peptidase (IRAP), also known as the AT4 receptor. LÄS MER
Sammanfattning : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. LÄS MER
Sammanfattning : The liquid crystal state is a complex state with many kinds of different molecular attractive and repulsive forces that results in various kinds of phases. Since the pioneering works by Vorländer in the early 20th century, liquid crystal research has to a great extent been depending on careful systematic studies of the structure/property relationships in series of similar liquid crystalline materials. LÄS MER
Sammanfattning : This thesis deals with studies of ruthenium-catalyzed hydrogen transfer reactions for oxidations and racemization.Through optimisation of the substrate-selective redox catalyst, the electron and proton transfer mediator (a benzoquinone derivative), and the oxygen-activating metal macrocycle a highly efficient biomimetic oxidation of secondary alcohols was obtained. LÄS MER
5. Computational Studies of Macrocycles and Molecular Modeling of Hepatitis C Virus NS3 Protease Inhibitors
Sammanfattning : Computational tools are utilized in the drug discovery process to discover, design, and optimize new therapeutics. One important approach is structure-based drug design which relies on knowledge about the 3D structure of the biological target. LÄS MER