Sökning: "macrocycle"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet macrocycle.

1. 1. Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)

   Författare :Hanna Andersson; Anders Hallberg; Anders Karlén; Federico Corelli; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiotensin IV; AT4; insulin-regulated aminopeptidase IRAP ; inhibitor; peptidomimetics; γ-turn mimetic; macrocycle; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Peptidomimetics derived from the bioactive hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) have been designed and synthesized. These peptidomimetics are aimed at inhibiting the insulin-regulated amino peptidase (IRAP), also known as the AT4 receptor. LÄS MER

3. 2. Design and Synthesis of Malarial Aspartic Protease Inhibitors

   Författare :Karolina Ersmark; Anders Hallberg; Michael Rowley; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; malaria; plasmepsin; aspartic protease; protease inhibitor; macrocycle; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

   Sammanfattning : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. LÄS MER

4. 3. Liquid Crystalline SIloxane Dimers - Advanced Materials with Enhanced Properties

   Författare :Nils Olsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 45 degree tilt angle; dimer; antiferroelectric; fluorinated; siloxane; polymer; liquid crystal; macrocycle; ferroelectric;

   Sammanfattning : The liquid crystal state is a complex state with many kinds of different molecular attractive and repulsive forces that results in various kinds of phases. Since the pioneering works by Vorländer in the early 20th century, liquid crystal research has to a great extent been depending on careful systematic studies of the structure/property relationships in series of similar liquid crystalline materials. LÄS MER

5. 4. Computational Modeling of Macrocycles and Structure-Based Design of Novel Antibacterial Compounds

   Författare :Gustav Olanders; Anders Karlén; Peter Brandt; Christian Sköld; Dan Sindhikara; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrocycles; docking; conformational sampling; conformational prefer-ences; antibiotics;

   Sammanfattning : The integration of computational methods into the drug discovery process provides valuable tools to help advance new and improved drugs into the clinic. As medicinal chemists explore novel targets and new areas of chemical space, our computational toolkit must also evolve. LÄS MER

7. 5. Studies of Biomimtic Oxidations and Racemizations

   Författare :Gábor Csjernyik; Jan-Erling Bäckvall; Serafino Gladiali; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; oxidation of alcohols; ruthenium; porphyrin; racemization;

   Sammanfattning : This thesis deals with studies of ruthenium-catalyzed hydrogen transfer reactions for oxidations and racemization.Through optimisation of the substrate-selective redox catalyst, the electron and proton transfer mediator (a benzoquinone derivative), and the oxygen-activating metal macrocycle a highly efficient biomimetic oxidation of secondary alcohols was obtained. LÄS MER