Sökning: "protease"

Visar resultat 1 - 5 av 444 avhandlingar innehållade ordet protease.

  1. 1. Design and Synthesis of Serine and Aspartic Protease Inhibitors

    Detta är en avhandling från Institutionen för fysik, kemi och biologi

    Författare :Fredrik Wångsell; Ingemar Kvarnström; Olle Karlsson; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes;

    Sammanfattning : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. LÄS MER

  2. 2. Cyclic Sulfamide HIV-1 Protease Inhibitors Design, Synthesis and Modelling

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Ax; Anders Karlén; Anders Hallberg; Tommy Liljefors; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; AIDS; HIV; protease inhibitor; aspartic protease; molecular modelling; 3D-QSAR; CoMFA; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi;

    Sammanfattning : Ten years ago, the first protease inhibitor targeting the human immunodeficiency virus (HIV) was approved for clinical use. Highly active antiretroviral therapy (HAART), which combined protease and reverse transcriptase inhibitors, quickly became the standard therapy for treating patients infected with HIV and Acquired Immune Deficiency Syndrome (AIDS). LÄS MER

  3. 3. Regulation of a Transcription Factor Activating Protease

    Detta är en avhandling från Stockholm University

    Författare :Deike J. Omnus; Per O. Ljungdahl; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Latent Transcription Factors; Protease; Phosphorylation; Proteasome; Signal Transduction; NATURAL SCIENCES Biology Cell and molecular biology Cell biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Cellbiologi; Cellbiology; cellbiologi;

    Sammanfattning : .... LÄS MER

  4. 4. Design and synthesis of HIV-1 protease inhibitors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mathias Alterman; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV-1; Protease; Inhibitors; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : Human Immunodeficiency Virus (HIV) is the causative agent of Acquired Immune Deficiency Syndrome (AIDS). The C2-symmetric HIV-1 protease is one of the prime targets for chemotherapy in the treatment of the HIV infection. Inhibition of HIV-1 protease leads to immature and non-infectious viral particles. LÄS MER

  5. 5. Design and Synthesis of Malarial Aspartic Protease Inhibitors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Karolina Ersmark; Anders Hallberg; Michael Rowley; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; malaria; plasmepsin; aspartic protease; protease inhibitor; macrocycle; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi;

    Sammanfattning : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. LÄS MER