Sökning: "protease"
Visar resultat 1 - 5 av 477 avhandlingar innehållade ordet protease.
1. Design and Synthesis of Serine and Aspartic Protease Inhibitors
Sammanfattning : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. LÄS MER
2. Cyclic Sulfamide HIV-1 Protease Inhibitors : Design, Synthesis and Modelling
Sammanfattning : Ten years ago, the first protease inhibitor targeting the human immunodeficiency virus (HIV) was approved for clinical use. Highly active antiretroviral therapy (HAART), which combined protease and reverse transcriptase inhibitors, quickly became the standard therapy for treating patients infected with HIV and Acquired Immune Deficiency Syndrome (AIDS). LÄS MER
3. Regulation of a Transcription Factor Activating Protease
Sammanfattning : .... LÄS MER
4. Design and synthesis of HIV-1 protease inhibitors
Sammanfattning : Human Immunodeficiency Virus (HIV) is the causative agent of Acquired Immune Deficiency Syndrome (AIDS). The C2-symmetric HIV-1 protease is one of the prime targets for chemotherapy in the treatment of the HIV infection. Inhibition of HIV-1 protease leads to immature and non-infectious viral particles. LÄS MER
5. Design and Synthesis of Malarial Aspartic Protease Inhibitors
Sammanfattning : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. LÄS MER