Sökning: "transition state mimetic"

Hittade 2 avhandlingar innehållade orden transition state mimetic.

  1. 1. Design and Synthesis of Aspartic and Serine Protease Inhibitors : Targeting the BACE-1 and the HCV NS3 Protease

    Författare :Fredrik Wångsell; Mats Larhed; Jari Yli-Kauhaluoma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; BACE-1; transition state mimetic; tertiary hydroxyl group; hydroxyethylene; statine; hydroxyethylamine; hepatitis C; HCV NS3; bioisostere; protease inhibitor.; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : This thesis describes work done to design and synthesize protease inhibitors, with the intention of developing therapeutic agents for Alzheimer’s disease (AD) and the chronic liver condition caused by infection of the hepatitis C virus (HCV). AD is the most common form of dementia, and HCV infection is the primary reason for liver transplantation in industrialized countries. LÄS MER

  3. 2. Xyloglucan-based polymers and nanocomposites – modification, properties and barrier film applications

    Författare :Joby Kochumalayil Jose; Lars Berglund; José M. Kenny; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; xyloglucan; packaging; oxygen barrier; nanocomposites;

    Sammanfattning : Biopolymers from renewable resources are of interest for packaging applications as an alternative to conventional petroleum-based polymers. One of the major application areas for biopolymers is food packaging, where a candidate polymer should meet critical requirements such as mechanical and oxygen barrier performance, also in humid conditions. LÄS MER