Sökning: "Farmaceutisk kemi"
Visar resultat 1 - 5 av 124 avhandlingar innehållade orden Farmaceutisk kemi.
1. Chiral Separation of Amines by Non-Aqueous Capillary Electrophoresis using Low Molecular Weight Selectors
Sammanfattning : Three chiral selectors (diketogulonic acid, benzoxycarbonylglycylproline and ketopinic acid) have been introduced for enantioseparation of pharmacologically active amines in non-aqueous capillary electrophoresis. The use of organic solvents, instead of aqueous buffers in the background electrolyte facilitated ion-pair formation between the analytes and the chiral selectors. LÄS MER
Sammanfattning : Sample preparation as the first step in an analytical procedure has an important role, particularly in bioanalysis, because of the complexity of biological samples (blood plasma and urine). Biological matrix such as plasma and blood contains proteins, organic and inorganic salts, acids, bases and various organic compounds with similar chemistry to the analytes of interest. LÄS MER
Sammanfattning : The signaling within and between cells in biology is governed by molecular recognition between natural or synthetic ligands and proteins. This thesis project aimed to investigate the thermodynamic properties of specific interaction between synthetic ligands and galectin proteins. LÄS MER
4. Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide
Sammanfattning : This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C.Two methods for the synthesis of 11C-labelled acrylamides have been explored. LÄS MER
5. Development of analytical methods for the determination of the small molecule component of complex biological systems
Sammanfattning : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. LÄS MER