Sökning: "Knud J. Jensen"

Hittade 2 avhandlingar innehållade orden Knud J. Jensen.

1. 1. Peptide Conjugates as Useful Molecular Tools

   Författare :Adam T. Ślósarczyk; Lars Baltzer; Knud J. Jensen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide conjugates; designed peptides; polypeptides; molecular recognition; linker; linking technology; bioconjugation; conjugation; conjugates; Kemi; Chemistry; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

   Sammanfattning : The conjugation of a small organic molecule to synthetic polypeptides from a designed set has been shown to give rise to binders with high affinity and selectivity for the phosphorylated model proteins α-casein and β-casein but not for ovoalbumin. The small organic molecule that was used for this purpose is comprised of two di-(2-picolyl)amine groups assembled on a dimethylphenyl scaffold, and is capable of complexing two Zn2+ ions to form chelates that bind the phosphate ion. LÄS MER

3. 2. Tertiary Alcohol- or β-Hydroxy γ-Lactam-Based HIV-1 Protease Inhibitors : Microwave Applications in Batch and Continuous Flow Organic Synthesis

   Författare :Per Öhrngren; Mats Larhed; Knud J. Jensen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; HIV; AIDS; protease inhibitor; aspartic protease; lactam; tertiary alcohol; continuous-flow; microwave; non-resonant; MAOS; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Since the outbreak of the HIV/AIDS pandemic in the 1980s, the disease has cost the lives of over 30 million people, and a further 33 million are currently living with the HIV infection. With the appropriate treatment, HIV/AIDS can today be regarded as a chronic but manageable disease. LÄS MER