Sökning: "Chromosomal instability"
Visar resultat 1 - 5 av 45 avhandlingar innehållade orden Chromosomal instability.
1. Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
Sammanfattning : In this thesis, telomere deficiency with subsequent anaphase bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural chromosomal aberrations and was also associated with the presence of multipolar mitoses. LÄS MER
2. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours
Sammanfattning : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. LÄS MER
3. Intrinsic radiosensitivity and molecular targets for tumour radiosensitization of head and neck cancer. With special reference to chromosomal instability and pentoxifylline
Sammanfattning : .... LÄS MER
4. Rectal Cancer - Tumor Biology and Prognostic Markers
Sammanfattning : Colorectal cancer is one of our most common malignancies and the second leading cause of cancer death worldwide. About 1/3 of the tumors are located in the rectum. LÄS MER
5. Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes
Sammanfattning : In this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. LÄS MER