Sökning: "telomeres"

Visar resultat 1 - 5 av 59 avhandlingar innehållade ordet telomeres.

  1. 1. Analysis of Immunoglobulin Genes and Telomeres in B cell Lymphomas and Leukemias

    Författare :Sarah Walsh; Richard Rosenquist; Christer Sundström; Anna Laurell; Andreas Rosenwald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma leukemia; mantle cell lymphoma; hairy cell leukemia; lymphoplasmacytic lymphoma; immunoglobulin genes; antigen selection; telomeres; cellular origin; somatic hypermutation; Genetik; Clinical genetics; Klinisk genetik;

    Sammanfattning : B cell lymphomas and leukemias are heterogeneous tumors with different cellular origins. Analysis of immunoglobulin (Ig) genes enables insight into the B cell progenitor, as Ig somatic hypermutation correlates with antigen-related B cell transit through the germinal center (GC). LÄS MER

  3. 2. Telomeres in ecology and evolution: Hypotheses and connections between telomere length, infections and life history trade-offs

    Författare :David Gomez Blanco; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; telomeres; life history; telomere elongation; telomere shortening; early-life telomere length; critical threshold; malaria infection; great reed warbler; Acrocephalus arundinaceus;

    Sammanfattning : Studying life history strategies is crucial for understanding the diversity among organisms. The trade-offs in traits related to survival, self-maintenance and reproduction play an important role in the variation of life histories and can be adjusted in response to environmental and physiological factors. LÄS MER

  4. 3. Telomeres and the brain : an investigation into the relationships of leukocyte telomere length with functional and structural attributes of the brain

    Författare :Mikael Wikgren; Karl-Fredrik Norrback; Rolf Adolfsson; Göran Roos; Thomas Karlsson; Brenda Penninx; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; aging; atrophy; brain; cognition; cortisol; depression; hippocampus; HPA axis; MRI; stress; telomere length; white matter hyper-intensities.;

    Sammanfattning : Telomeres are the outermost parts of linear chromosomes. They consist of tandemly repeated non-coding short nucleotide sequences (TTAGGG in all vertebrates), in humans spanning over the last 2 to 15 kilobase pairs of the chromosome. Due to the end-replication problem, telomeres shorten with each cellular division. LÄS MER

  5. 4. Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes

    Författare :Gisela Lundberg; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; MYCN; telomeres; chromosomal instability;

    Sammanfattning : In this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. LÄS MER

  7. 5. Molecular ecology of marine mammals

    Författare :Morten Tange Olsen; Per Palsbøll; Martine Bérubé; William “Bill” Amos; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Marine mammals; molecular ecology; life history; environmental change; phenotypic plasticity; SNPs; telomeres; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Marine mammals comprise a paraphyletic group of species whose current abundance and distribution has been greatly shaped by past environmental changes and anthropogenic impacts. This thesis describes molecular ecological approaches to answer questions regarding habitat requirements, genetic differentiation, and life-history trade-offs in three species of marine mammals. LÄS MER