Sökning: "structural rearrangement"
Visar resultat 1 - 5 av 34 avhandlingar innehållade orden structural rearrangement.
1. Structural transitions of proton-gated ion channels : Involving pH sensing, heterogeneity and lipid interactions
Sammanfattning : Studying protein structure and function involves analyzing the relationship between a protein's three-dimensional assembly and its dynamic biochemical activity. The superfamily of pentameric ligand-gated ion channels (pLGICs) constitutes a classic yet illuminating experimental system for structure-function studies. LÄS MER
2. Investigation of Mechanics of Mutation and Selection by Comparative Sequencing
Sammanfattning : The process of evolution is of both scientific and medical interest. This thesis presents several studies using complete genomic reference sequences, comparative genomic data, and intraspecific diversity data to study the two key processes of evolution: mutation and selection. LÄS MER
3. Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
Sammanfattning : In this thesis, telomere deficiency with subsequent anaphase bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural chromosomal aberrations and was also associated with the presence of multipolar mitoses. LÄS MER
4. Structural genomic variation in human disease
Sammanfattning : Structural variants (SVs) are physical changes in the structure of chromosomes and include both unbalanced copy number variants (CNVs) and balanced events (translocations, inversions and insertions). Many SVs constitute benign background variation and are found frequently in healthy individuals. LÄS MER
5. Energy Transduction and Sensory Signalling in Haloarchaea Structural Characterisation of the Photocycles of Bacteriorhodopsin and Sensory Rhodopsin II
Sammanfattning : Archaeal rhodopsins belong a subfamily of heptahelical transmembrane proteins. All contain a buried retinal chromophore covalently bound to a conserved lysine residue in helix G via a protonated Schiff base. LÄS MER