Sökning: "G2 checkpoint"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden G2 checkpoint.

  1. 1. Intrinsic radiosensitivity and molecular targets for tumour radiosensitization of head and neck cancer. With special reference to chromosomal instability and pentoxifylline

    Författare :Anna Danielsson; Göteborgs universitet; []
    Nyckelord :radiosensitivity; clonogenic survival; radio-sensitizer; chromosomal instability; cell cycle regulation; G2 checkpoint; pentoxifylline;

    Sammanfattning : .... LÄS MER

  3. 2. Regulation of G2 phase and long-term consequences of DNA damage

    Författare :Anna Won Middleton; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated events termed ‘the cell cycle’, which ensures cell proliferation proceeds with high fidelity. LÄS MER

  4. 3. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Författare :Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Sammanfattning : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. LÄS MER

  5. 4. Cell cycle regulation and DNA damage response : a record of polo-like kinase 1 activity

    Författare :Elvira Hukasova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Division and cell proliferation is an essence of life. A human cell has in its core a very simple yet a very complex machinery to coordinate cell cycle activities and events. LÄS MER

  7. 5. Tracing the interplay between cellular metabolism and cell cycle

    Författare :Irena Roci; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer cells are more vulnerable to targeting during S-G2-M cell cycle phases due to common deregulations in cell cycle checkpoint mechanisms. Most common cancer drugs target processes in the S-G2-M phases, often causing negative effects on proliferating normal cells. LÄS MER