Sökning: "Chromosomal instability"

Visar resultat 21 - 25 av 45 avhandlingar innehållade orden Chromosomal instability.

1. 21. Integrative genomic and survival analysis of breast tumors

   Författare :Szilard Nemes; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biostatistics; cancer; survival analysis; gemonics; DNA copy number aberrations; messenger RNA;

   Sammanfattning : With the continued accumulation of genomic data at ever increasing resolution the challenge ahead lies in reading out meaningful clinical/biological information form the data that can contribute to a better understanding of the cancerous process. The need for novel approaches, new statistical methods is therefore strong. LÄS MER

3. 22. Trinucleotide repeats and neuropsychiatric phenotypes

   Författare :Qiu-Ping Yuan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Trinucleotide; repeat expansion; psychiatric disorder; gene; spastic paraplegia;

   Sammanfattning : Genetic studies of affective disorders have yielded several chromosomal regions suggestive for linkage. Linkage analysis was performed in five families with unipolar affective disorder, collected from northern Sweden. Four candidate regions on chromosomes 16, 18, 21 and 4p were excluded. LÄS MER

4. 23. Tumor Suppressor function of the deubiquitinating enzyme BAP1 and its substrate gamma-tubulin In regulation of cell cycle and genome stability

   Författare :Reihaneh Zarrizi; Avdelningen för translationell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : In normal cells, the cell cycle is controlled by a complex series of signalling pathways by which a cell grows, replicates its DNA and divides. The critical task of the cell cycle is to ensure that DNA is faithfully replicated and that identical chromosomal copies are distributed equally to two daughter cells during mitosis with the help of the mitotic spindle. LÄS MER

5. 24. The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes

   Författare :Helena Carén; Göteborgs universitet; []
   Nyckelord :cancer; neuroblastoma; epigenetics; DNA methylation; microarray; tumor suppressor gene; tumor; embryonal; neural crest; bisulfite sequencing; 1p36; 11q; MYCN; CASZ1; PIK3CD; PRKCDBP; SCNN1A; TGFBI; DHRS3; KRT19; DUSP23; APITD1; H2AFX;

   Sammanfattning : Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment in these young children can also be severe. LÄS MER

7. 25. Novel methods to study genomic fragility and structural variation

   Författare :Reza Mirzazadeh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : DNA double-strand breaks (DSBs) are major DNA lesions that when repaired unfaithfully can give rise to loss of genetic information, chromosomal rearrangements such as insertions/deletions (indels) and copy number alterations (CNAs), which in turn lead to genomic instability that is characteristic of almost all cancer types. In this context, it is thought that genomic instability has critical roles in cancer initiation, progression and intra-tumor heterogeneity (ITH). LÄS MER