Sökning: "MYCN"

Visar resultat 1 - 5 av 38 avhandlingar innehållade ordet MYCN.

  1. 1. Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes

    Detta är en avhandling från Faculty of Medicine, Lund University

    Författare :Gisela Lundberg; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; MYCN; telomeres; chromosomal instability;

    Sammanfattning : In this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. LÄS MER

  2. 2. The Role of SOX9 in Medulloblastoma

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Vasil Savov; Fredrik Swartling; Ulrich Schüller; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; SOX9; MYCN; cancer development; recurrence; regulation; tumor metastasis; migration; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Overall survival is about 70% and in cases where current treatment fails, the disease recurs and most often is fatal. At the molecular level, MB can be divided into four defined subgroups: WNT, SHH, Group 3 and Group 4. LÄS MER

  3. 3. Polyamine analogues inhibit neuroblastoma cell growth

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Erika Söderstjerna; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; survivin; cell cycle; polyamine analogue; polyamines; apoptosis; neuroblastoma; MYCN;

    Sammanfattning : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. LÄS MER

  4. 4. Hypoxia and differentiation in human neuroblastoma cells

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Helén Nilsson; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ontogeny; embryology human ; Utvecklingsbiologi; teratologi; embryologi människa ; teratology; cytogenetik; Development biology; cytogenetics; Genetik; Genetics; Medicin människa och djur ; HIF; Medicine human and vertebrates ; MYCN; Hypoxia; differentiation; Neuroblastoma;

    Sammanfattning : The childhood tumour neuroblastoma is derived from immature cells of the sympathetic nervous system, which have become arrested at different maturation stages. Neuroblastoma is a malignancy with a high degree of heterogeneity, and there is a correlation between a poor differentiation status and a more aggressive phenotype. LÄS MER

  5. 5. Oncogenic ALK signaling in neuroblastoma

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Ganesh Umapathy; Göteborgs universitet.; Gothenburg University.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; neuroblastoma; ERK5; Akt; MYCN; mTOR;

    Sammanfattning : Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. LÄS MER