Sökning: "protein factors"

Visar resultat 11 - 15 av 2112 avhandlingar innehållade orden protein factors.

1. 11. Characterization and Engineering of Protein-Protein Interactions Involving PDZ Domains

   Författare :Andreas Karlsson; Per Jemth; Daniel Otzen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered protein regions; PDZ domain; binding kinetics; protein engineering; interaction mechanism; specificity; PDZbody; Chemistry with specialization in Biophysics; Kemi med inriktning mot biofysik;

   Sammanfattning : The work presented in this thesis has contributed with knowledge to several aspects of protein-protein interaction involving PDZ domains. A substantial amount of our proteome contains regions that are intrinsically disordered but fold upon ligand interaction. LÄS MER

3. 12. The p97 ATPase and the Drosophila Proteasome : Protein Unfolding and Regulation

   Författare :Kristian Björk Grimberg; Patrick Young; Neus Visa; Lars Thelander; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proteasome; ubiquitin; p97; unfolding; regulation; RNAi screen; high-throughput screen; cnc; basic leucine zipper; transcription factors; proteasome inhibition; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

   Sammanfattning : For all living systems, there is a requirement to recycle and regulate proteins. In eukaryotic organisms this is accomplished by the proteasome. The p97 ATPase is another highly conserved and essential complex present throughout the eukaryotic cell. LÄS MER

4. 13. Anticoagulant protein C--structural and functional studies

   Författare :Lei Shen; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymology; Proteins; Klinisk kemi; Clinical chemistry; serpins; membrane binding; factor V; protein C; protein S; Proteiner; enzymologi;

   Sammanfattning : Anticoagulant protein C is a vitamin K-dependent factor circulating in plasma as a zymogen of a serine protease. It is converted to its active form (APC) by the thrombin-thrombomodulin complex on the surface of endothelial cells. APC inhibits the generation of thrombin by selective proteolytic inactivation procoagulant factors Va and VIIIa. LÄS MER

5. 14. Interaction of Triglyceride-rich Lipoproteins with Platelets and Vitamin K-dependent Coagulation Factors

   Författare :Ning Xu; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Triglycerides.; Prothrombin; Protein S; Protein C; Platelets; Phospholipids; Metabolism; Lipoproteins; Lipids; Endocytosis; Electron microscopy; Cytochemistry; Coronary heart disease; Blood coagulation factors; Arachidonic acid; Atherosclerosis; Clinical chemistry; Klinisk kemi; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

   Sammanfattning : 1. During incubation of platelets with 3H-arachidonic acid (20:4, n-6) and 14C-cholesterol doubly labelled and colloidal gold labelled chylomicrons (CMs) and chylomicron remnants (CMRs) CMs were taken up more efficiently than CMRs. Addition of unlabelled CMs, VLDLs, LDLs and HDLs decreased the uptake of labelled CMs. LÄS MER

7. 15. Protein Folding Studies on the Ribosomal Protein S6: the Role of Entropy in Nucleation

   Författare :Magnus Lindberg; Mikael Oliveberg; Jane Clarke; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; protein folding; circular permutation; topology; connectivity; entropy; protein stability; chevron plot; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

   Sammanfattning : One of the most challenging tasks remaining in the field of biochemistry is the one of understanding how the information within the amino acid sequence of proteins translates into a unique structure. Solving this problem would lead to endless possibilities for application in the medical and biotechnology industry. LÄS MER