Sökning: "PDZ domain"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden PDZ domain.

1. 1. Protein Folding, Binding and Evolution : PDZ domains and paralemmins as model systems

   Författare :Greta Hultqvist; Per Jemth; Ruth Nussinov; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein folding; evolution; binding; allostery; Paralemmin; PDZ domain;

   Sammanfattning : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. LÄS MER

3. 2. Mucins, Cystic Fibrosis and PDZ protein interactions

   Författare :Emily Malmberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; PDZ; transmembrane; MUC1; Cystic Fibrosis; clathrin; CFTR; PDZK1; Bcr; endocytosis; MUC17;

   Sammanfattning : Cystic Fibrosis (CF) is caused and characterized by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The dominating feature of the disease is mucus accumulation on mucosal surfaces, but no direct functional connection between mucus and CFTR is known. LÄS MER

4. 3. Characterization and Engineering of Protein-Protein Interactions Involving PDZ Domains

   Författare :Andreas Karlsson; Per Jemth; Daniel Otzen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered protein regions; PDZ domain; binding kinetics; protein engineering; interaction mechanism; specificity; PDZbody; Chemistry with specialization in Biophysics; Kemi med inriktning mot biofysik;

   Sammanfattning : The work presented in this thesis has contributed with knowledge to several aspects of protein-protein interaction involving PDZ domains. A substantial amount of our proteome contains regions that are intrinsically disordered but fold upon ligand interaction. LÄS MER

5. 4. Functional characterization of interactions between the flavivirus NS5 protein and PDZ proteins of the mammalian host

   Författare :Karin Ellencrona; Magnus Johansson; Andrew Davidson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus TBEV ; West-Nile virus WNV ; Dengue virus DENV ; flavivirus; PDZ domains; ZO-2; ZO-1; RIMS2; Scribble; Interferon; JAK-STAT signaling; PDZ array; virus-host protein interaction; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

   Sammanfattning : Flaviviruses are found all over the world and affect and infect millions of people every year. Flavivirus infection can lead to severe clinical outcomes resulting in neuronal damages e.g. Tick-borne encephalitis virus (TBEV), or severe hemorrhagic fevers e. LÄS MER

7. 5. Exploring the Role of the PDZ Domain in a Supramodule

   Författare :Louise Laursen; Per Jemth; Per Hammarström; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PSD-95; PSG; PDZ3; supramodule; liquid liquid phase separation; allostery; folding; binding; evolution; post synaptic density; SynGap; CRIPT; AGRB1; Medical Biochemistry; Medicinsk biokemi; Medical Biochemistry; Medicinsk biokemi;

   Sammanfattning : The postsynaptic density (PSD) is a large, dense and membraneless compartment of proteins associated below the postsynaptic membrane bilayer, and which constantly undergoes morphological alteration in response to synaptic activity. Formation of PSD is associated with liquid-liquid phase separation of scaffold proteins in complex with other PSD proteins. LÄS MER